EIF6

From Wikipedia, the free encyclopedia

Integrin beta 4 binding protein

Identifiers

ITGB4BP; CAB; EIF3A; EIF6; b(2)gcn; p27BBP

External IDs

OMIM: 602912 MGI: 1196288 HomoloGene: 7135

Gene ontology
Molecular Function:	• translation initiation factor activity • protein binding • ribosome binding
Cellular Component:	• nucleus • lamin filament
Biological Process:	• translation • integrin-mediated signaling pathway • mature ribosome assembly

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_002212 (mRNA)
NP_002203 (protein)

NM_010579 (mRNA)
NP_034709 (protein)

Location

Chr 20: 33.33 - 33.34 Mb

Chr 2: 155.51 - 155.52 Mb

Pubmed search

[1]

[2]

Integrin beta 4 binding protein, also known as ITGB4BP, is a human gene.^[1]

Hemidesmosomes are structures which link the basal lamina to the intermediate filament cytoskeleton. An important functional component of hemidesmosomes is the integrin beta-4 subunit (ITGB4), a protein containing two fibronectin type III domains. The protein encoded by this gene binds to the fibronectin type III domains of ITGB4 and may help link ITGB4 to the intermediate filament cytoskeleton. The encoded protein, which is insoluble and found both in the nucleus and in the cytoplasm, can function as a translation initiation factor and prevent the association of the 40S and 60S ribosomal subunits. Multiple transcript variants encoding several different isoforms have been found for this gene.^[1]

[edit] References

^ ^a ^b Entrez Gene: ITGB4BP integrin beta 4 binding protein.

[edit] Further reading

Biffo S, Sanvito F, Costa S, et al. (1997). "Isolation of a novel beta4 integrin-binding protein (p27(BBP)) highly expressed in epithelial cells.". J. Biol. Chem. 272 (48): 30314-21. PMID 9374518.
Si K, Chaudhuri J, Chevesich J, Maitra U (1998). "Molecular cloning and functional expression of a human cDNA encoding translation initiation factor 6.". Proc. Natl. Acad. Sci. U.S.A. 94 (26): 14285-90. PMID 9405604.
Mao M, Fu G, Wu JS, et al. (1998). "Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning.". Proc. Natl. Acad. Sci. U.S.A. 95 (14): 8175-80. PMID 9653160.
Sanvito F, Arrigo G, Zuffardi O, et al.. "Localization of p27 beta4 binding protein gene (ITGB4BP) to human chromosome region 20q11.2" 52 (1): 111-2. doi:10.1006/geno.1998.5403. PMID 9740680.
Sanvito F, Piatti S, Villa A, et al. (1999). "The beta4 integrin interactor p27(BBP/eIF6) is an essential nuclear matrix protein involved in 60S ribosomal subunit assembly.". J. Cell Biol. 144 (5): 823-37. PMID 10085284.
Sanvito F, Arrigo G, Zuffardi O, et al. (1999). "Localization of p27 beta 4 binding protein gene (ITGB4BP) to human chromosome region 20q11.2.". Genomics 52 (1): 111-2. PMID 10348637.
Wixler V, Geerts D, Laplantine E, et al. (2000). "The LIM-only protein DRAL/FHL2 binds to the cytoplasmic domain of several alpha and beta integrin chains and is recruited to adhesion complexes.". J. Biol. Chem. 275 (43): 33669-78. doi:10.1074/jbc.M002519200. PMID 10906324.
Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.". Genome Res. 10 (10): 1546-60. PMID 11042152.
Donadini A, Giodini A, Sanvito F, et al. (2001). "The human ITGB4BP gene is constitutively expressed in vitro, but highly modulated in vivo.". Gene 266 (1-2): 35-43. PMID 11290417.
Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20.". Nature 414 (6866): 865-71. doi:10.1038/414865a. PMID 11780052.
Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus.". Curr. Biol. 12 (1): 1-11. PMID 11790298.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Basu U, Si K, Deng H, Maitra U (2003). "Phosphorylation of mammalian eukaryotic translation initiation factor 6 and its Saccharomyces cerevisiae homologue Tif6p: evidence that phosphorylation of Tif6p regulates its nucleocytoplasmic distribution and is required for yeast cell growth.". Mol. Cell. Biol. 23 (17): 6187-99. PMID 12917340.
Ceci M, Gaviraghi C, Gorrini C, et al. (2003). "Release of eIF6 (p27BBP) from the 60S subunit allows 80S ribosome assembly.". Nature 426 (6966): 579-84. doi:10.1038/nature02160. PMID 14654845.
Rosso P, Cortesina G, Sanvito F, et al. (2004). "Overexpression of p27BBP in head and neck carcinomas and their lymph node metastases.". Head Neck 26 (5): 408-17. doi:10.1002/hed.10401. PMID 15122657.
Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation.". Genome Res. 14 (7): 1315-23. doi:10.1101/gr.2122004. PMID 15231747.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.". Nat. Biotechnol. 23 (1): 94-101. doi:10.1038/nbt1046. PMID 15592455.
Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics.". Nature 433 (7021): 77-83. doi:10.1038/nature03207. PMID 15635413.
Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome.". Cell 122 (6): 957-68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.