EIF5

From Wikipedia, the free encyclopedia

Eukaryotic translation initiation factor 5

PDB rendering based on 2g2k.

Available structures: 2g2k, 2iu1

Identifiers

Symbol(s)

EIF5; EIF-5A

External IDs

OMIM: 601710 MGI: 95309 HomoloGene: 49610

Gene ontology
Molecular Function:	• nucleotide binding • translation initiation factor activity • GTPase activity • GTP binding
Cellular Component:	• cytoplasm • cytosol
Biological Process:	• regulation of translational initiation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001969 (mRNA)
NP_001960 (protein)

NM_173363 (mRNA)
NP_775539 (protein)

Location

Chr 14: 102.87 - 102.88 Mb

Chr 12: 111.99 - 111.99 Mb

Pubmed search

[1]

[2]

Eukaryotic translation initiation factor 5, also known as EIF5, is a human gene.^[1]

[edit] References

^ Entrez Gene: EIF5 eukaryotic translation initiation factor 5.

[edit] External links

Cap-dependent translation initiation from Nature Reviews Microbiology. A good image and overview of the function of initiation factors

[edit] Further reading

Si K, Das K, Maitra U (1996). "Characterization of multiple mRNAs that encode mammalian translation initiation factor 5 (eIF-5).". J. Biol. Chem. 271 (28): 16934–8. PMID 8663286.
Das S, Maiti T, Das K, Maitra U (1998). "Specific interaction of eukaryotic translation initiation factor 5 (eIF5) with the beta-subunit of eIF2.". J. Biol. Chem. 272 (50): 31712–8. PMID 9395514.
Bandyopadhyay A, Maitra U (1999). "Cloning and characterization of the p42 subunit of mammalian translation initiation factor 3 (eIF3): demonstration that eIF3 interacts with eIF5 in mammalian cells.". Nucleic Acids Res. 27 (5): 1331–7. PMID 9973622.
Das S, Maitra U (2000). "Mutational analysis of mammalian translation initiation factor 5 (eIF5): role of interaction between the beta subunit of eIF2 and eIF5 in eIF5 function in vitro and in vivo.". Mol. Cell. Biol. 20 (11): 3942–50. PMID 10805737.
Choi SK, Olsen DS, Roll-Mecak A, et al. (2000). "Physical and functional interaction between the eukaryotic orthologs of prokaryotic translation initiation factors IF1 and IF2.". Mol. Cell. Biol. 20 (19): 7183–91. PMID 10982835.
Das S, Ghosh R, Maitra U (2001). "Eukaryotic translation initiation factor 5 functions as a GTPase-activating protein.". J. Biol. Chem. 276 (9): 6720–6. doi:10.1074/jbc.M008863200. PMID 11092890.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422–35. doi:10.1101/gr.154701. PMID 11230166.
Asano K, Shalev A, Phan L, et al. (2001). "Multiple roles for the C-terminal domain of eIF5 in translation initiation complex assembly and GTPase activation.". EMBO J. 20 (9): 2326–37. doi:10.1093/emboj/20.9.2326. PMID 11331597.
Majumdar R, Bandyopadhyay A, Deng H, Maitra U (2002). "Phosphorylation of mammalian translation initiation factor 5 (eIF5) in vitro and in vivo.". Nucleic Acids Res. 30 (5): 1154–62. PMID 11861906.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Marintchev A, Kolupaeva VG, Pestova TV, Wagner G (2003). "Mapping the binding interface between human eukaryotic initiation factors 1A and 5B: a new interaction between old partners.". Proc. Natl. Acad. Sci. U.S.A. 100 (4): 1535–40. doi:10.1073/pnas.0437845100. PMID 12569173.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Homma MK, Wada I, Suzuki T, et al. (2005). "CK2 phosphorylation of eukaryotic translation initiation factor 5 potentiates cell cycle progression.". Proc. Natl. Acad. Sci. U.S.A. 102 (43): 15688–93. doi:10.1073/pnas.0506791102. PMID 16227438.
Conte MR, Kelly G, Babon J, et al. (2006). "Structure of the eukaryotic initiation factor (eIF) 5 reveals a fold common to several translation factors.". Biochemistry 45 (14): 4550–8. doi:10.1021/bi052387u. PMID 16584190.
Bieniossek C, Schütz P, Bumann M, et al. (2006). "The crystal structure of the carboxy-terminal domain of human translation initiation factor eIF5.". J. Mol. Biol. 360 (2): 457–65. doi:10.1016/j.jmb.2006.05.021. PMID 16781736.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.