EIF4G2

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Eukaryotic translation initiation factor 4 gamma, 2
Identifiers
Symbol(s) EIF4G2; NAT1; AAG1; DAP5; FLJ41344; p97
External IDs OMIM: 602325 MGI: 109207 HomoloGene: 37477
Orthologs
Human Mouse
Entrez 1982 13690
Ensembl ENSG00000110321 ENSMUSG00000005610
Uniprot P78344 A0JNY7
Refseq NM_001042559 (mRNA)
NP_001036024 (protein)		 NM_001040131 (mRNA)
NP_001035221 (protein)
Location Chr 11: 10.78 - 10.79 Mb Chr 7: 110.86 - 110.87 Mb
Pubmed search [1] [2]

Eukaryotic translation initiation factor 4 gamma, 2, also known as EIF4G2, is a human gene.

Translation initiation is mediated by specific recognition of the cap structure by eukaryotic translation initiation factor 4F (eIF4F), which is a cap binding protein complex that consists of three subunits: eIF4A, eIF4E and eIF4G. The protein encoded by this gene shares similarity with the C-terminal region of eIF4G that contains the binding sites for eIF4A and eIF3; eIF4G, in addition, contains a binding site for eIF4E at the N-terminus. Unlike eIF4G, which supports cap-dependent and independent translation, this gene product functions as a general repressor of translation by forming translationally inactive complexes. In vitro and in vivo studies indicate that translation of this mRNA initiates exclusively at a non-AUG (GUG) codon. Alternatively spliced transcript variants encoding different isoforms of this gene have been described.[1]

[edit] References

  1. ^ Entrez Gene: EIF4G2 eukaryotic translation initiation factor 4 gamma, 2.

[edit] Further reading

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171-4. PMID 8125298. 
  • Shaughnessy JD, Jenkins NA, Copeland NG (1997). "cDNA cloning, expression analysis, and chromosomal localization of a gene with high homology to wheat eIF-(iso)4F and mammalian eIF-4G.". Genomics 39 (2): 192-7. doi:10.1006/geno.1996.4502. PMID 9027506. 
  • Levy-Strumpf N, Deiss LP, Berissi H, Kimchi A (1997). "DAP-5, a novel homolog of eukaryotic translation initiation factor 4G isolated as a putative modulator of gamma interferon-induced programmed cell death.". Mol. Cell. Biol. 17 (3): 1615-25. PMID 9032289. 
  • Imataka H, Olsen HS, Sonenberg N (1997). "A new translational regulator with homology to eukaryotic translation initiation factor 4G.". EMBO J. 16 (4): 817-25. doi:10.1093/emboj/16.4.817. PMID 9049310. 
  • Imataka H, Sonenberg N (1997). "Human eukaryotic translation initiation factor 4G (eIF4G) possesses two separate and independent binding sites for eIF4A.". Mol. Cell. Biol. 17 (12): 6940-7. PMID 9372926. 
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149-56. PMID 9373149. 
  • Pyronnet S, Imataka H, Gingras AC, et al. (1999). "Human eukaryotic translation initiation factor 4G (eIF4G) recruits mnk1 to phosphorylate eIF4E.". EMBO J. 18 (1): 270-9. doi:10.1093/emboj/18.1.270. PMID 9878069. 
  • Marcotrigiano J, Gingras AC, Sonenberg N, Burley SK (1999). "Cap-dependent translation initiation in eukaryotes is regulated by a molecular mimic of eIF4G.". Mol. Cell 3 (6): 707-16. PMID 10394359. 
  • Henis-Korenblit S, Strumpf NL, Goldstaub D, Kimchi A (2000). "A novel form of DAP5 protein accumulates in apoptotic cells as a result of caspase cleavage and internal ribosome entry site-mediated translation.". Mol. Cell. Biol. 20 (2): 496-506. PMID 10611228. 
  • Marcotrigiano J, Lomakin IB, Sonenberg N, et al. (2001). "A conserved HEAT domain within eIF4G directs assembly of the translation initiation machinery.". Mol. Cell 7 (1): 193-203. PMID 11172724. 
  • Marissen WE, Gradi A, Sonenberg N, Lloyd RE (2001). "Cleavage of eukaryotic translation initiation factor 4GII correlates with translation inhibition during apoptosis.". Cell Death Differ. 7 (12): 1234-43. doi:10.1038/sj.cdd.4400750. PMID 11175261. 
  • Asano K, Shalev A, Phan L, et al. (2001). "Multiple roles for the C-terminal domain of eIF5 in translation initiation complex assembly and GTPase activation.". EMBO J. 20 (9): 2326-37. doi:10.1093/emboj/20.9.2326. PMID 11331597. 
  • Pyronnet S, Dostie J, Sonenberg N (2001). "Suppression of cap-dependent translation in mitosis.". Genes Dev. 15 (16): 2083-93. doi:10.1101/gad.889201. PMID 11511540. 
  • Henis-Korenblit S, Shani G, Sines T, et al. (2002). "The caspase-cleaved DAP5 protein supports internal ribosome entry site-mediated translation of death proteins.". Proc. Natl. Acad. Sci. U.S.A. 99 (8): 5400-5. doi:10.1073/pnas.082102499. PMID 11943866. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Perales C, Carrasco L, Ventoso I (2003). "Cleavage of eIF4G by HIV-1 protease: effects on translation.". FEBS Lett. 533 (1-3): 89-94. PMID 12505164. 
  • Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.". Nat. Biotechnol. 21 (5): 566-9. doi:10.1038/nbt810. PMID 12665801. 
  • Li Z, Hu CY, Mo BQ, et al. (2003). "[Effect of beta-carotene on gene expression of breast cancer cells]". Ai Zheng 22 (4): 380-4. PMID 12703993. 
  • Qin H, Raught B, Sonenberg N, et al. (2004). "Phosphorylation screening identifies translational initiation factor 4GII as an intracellular target of Ca(2+)/calmodulin-dependent protein kinase I.". J. Biol. Chem. 278 (49): 48570-9. doi:10.1074/jbc.M308781200. PMID 14507913. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039. 
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