EIF4ENIF1

From Wikipedia, the free encyclopedia

Eukaryotic translation initiation factor 4E nuclear import factor 1

Identifiers

EIF4ENIF1; 4E-T; Clast4; FLJ21601; FLJ26551

External IDs

OMIM: 607445 MGI: 1921453 HomoloGene: 10522

Gene ontology
Molecular Function:	• translation initiation factor activity • protein binding • protein transporter activity
Cellular Component:	• nucleus • cytoplasm
Biological Process:	• protein transport

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_019843 (mRNA)
NP_062817 (protein)

NM_023743 (mRNA)
NP_076232 (protein)

Location

Chr 22: 30.17 - 30.22 Mb

Chr 11: 3.1 - 3.14 Mb

Pubmed search

[1]

[2]

Eukaryotic translation initiation factor 4E nuclear import factor 1, also known as EIF4ENIF1, is a human gene.^[1]

The protein encoded by this gene is a nucleocytoplasmic shuttle protein for the translation initiation factor eIF4E. This shuttle protein interacts with the importin alpha-beta complex to mediate nuclear import of eIF4E. It is predominantly cytoplasmic;its own nuclear import is regulated by a nuclear localization signal and nuclear export signals.^[1]

[edit] References

^ ^a ^b Entrez Gene: EIF4ENIF1 eukaryotic translation initiation factor 4E nuclear import factor 1.

[edit] Further reading

Dostie J, Ferraiuolo M, Pause A, et al. (2000). "A novel shuttling protein, 4E-T, mediates the nuclear import of the mRNA 5' cap-binding protein, eIF4E.". EMBO J. 19 (12): 3142-56. doi:10.1093/emboj/19.12.3142. PMID 10856257.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Warner DR, Roberts EA, Greene RM, Pisano MM (2004). "Identification of novel Smad binding proteins.". Biochem. Biophys. Res. Commun. 312 (4): 1185-90. PMID 14651998.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Ballif BA, Villén J, Beausoleil SA, et al. (2005). "Phosphoproteomic analysis of the developing mouse brain.". Mol. Cell Proteomics 3 (11): 1093-101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.
Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome.". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMID 15461802.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Andrei MA, Ingelfinger D, Heintzmann R, et al. (2005). "A role for eIF4E and eIF4E-transporter in targeting mRNPs to mammalian processing bodies.". RNA 11 (5): 717-27. doi:10.1261/rna.2340405. PMID 15840819.
Ferraiuolo MA, Basak S, Dostie J, et al. (2005). "A role for the eIF4E-binding protein 4E-T in P-body formation and mRNA decay.". J. Cell Biol. 170 (6): 913-24. doi:10.1083/jcb.200504039. PMID 16157702.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514.
Wichroski MJ, Robb GB, Rana TM (2006). "Human retroviral host restriction factors APOBEC3G and APOBEC3F localize to mRNA processing bodies.". PLoS Pathog. 2 (5): e41. doi:10.1371/journal.ppat.0020041. PMID 16699599.
Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.". Cell 125 (4): 801-14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
Denoeud F, Kapranov P, Ucla C, et al. (2007). "Prominent use of distal 5' transcription start sites and discovery of a large number of additional exons in ENCODE regions.". Genome Res. 17 (6): 746-59. doi:10.1101/gr.5660607. PMID 17567994.