EIF4EBP3

From Wikipedia, the free encyclopedia

Eukaryotic translation initiation factor 4E binding protein 3

Identifiers

External IDs

OMIM: 603483 MGI: 1270847 HomoloGene: 37841

Gene ontology
Molecular Function:	• protein binding • eukaryotic initiation factor 4E binding • translation repressor activity
Cellular Component:	• eukaryotic translation initiation factor 4F complex
Biological Process:	• negative regulation of translational initiation

Orthologs

Human

Mouse

n/a

n/a

Refseq

NM_003732 (mRNA)
NP_003723 (protein)

NM_201256 (mRNA)
NP_957708 (protein)

Location

n/a

Chr 18: 36.79 - 36.79 Mb

Pubmed search

[1]

[2]

Eukaryotic translation initiation factor 4E binding protein 3, also known as EIF4EBP3, is a human gene.^[1]

This gene encodes a member of the EIF4EBP family which derives it name from proteins that bind to eukaryotic initiation factor 4E and that prevent its assembly into EIF4F. Co-transcription of this gene and the neighboring upstream gene (MASK) generates a transcript (MASK-BP3) which encodes a fusion protein comprised of the MASK protein sequence for the majority of the protein and a different C-terminus due to an alternate reading frame for the EIF4EBP3 segments.^[1]

[edit] References

^ ^a ^b Entrez Gene: EIF4EBP3 eukaryotic translation initiation factor 4E binding protein 3.

[edit] Further reading

Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Joshi B, Cameron A, Jagus R (2004). "Characterization of mammalian eIF4E-family members.". Eur. J. Biochem. 271 (11): 2189-203. doi:10.1111/j.1432-1033.2004.04149.x. PMID 15153109.
Poulin F, Brueschke A, Sonenberg N (2004). "Gene fusion and overlapping reading frames in the mammalian genes for 4E-BP3 and MASK.". J. Biol. Chem. 278 (52): 52290-7. doi:10.1074/jbc.M310761200. PMID 14557257.
Ferguson G, Mothe-Satney I, Lawrence JC (2004). "Ser-64 and Ser-111 in PHAS-I are dispensable for insulin-stimulated dissociation from eIF4E.". J. Biol. Chem. 278 (48): 47459-65. doi:10.1074/jbc.M307949200. PMID 14507920.
Kleijn M, Scheper GC, Wilson ML, et al. (2003). "Localisation and regulation of the eIF4E-binding protein 4E-BP3.". FEBS Lett. 532 (3): 319-23. PMID 12482586.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Poulin F, Gingras AC, Olsen H, et al. (1998). "4E-BP3, a new member of the eukaryotic initiation factor 4E-binding protein family.". J. Biol. Chem. 273 (22): 14002-7. PMID 9593750.