EIF4EBP2

From Wikipedia, the free encyclopedia

Eukaryotic translation initiation factor 4E binding protein 2

Identifiers

External IDs

OMIM: 602224 MGI: 109198 HomoloGene: 3022

Gene ontology
Molecular Function:	• protein binding • eukaryotic initiation factor 4E binding
Biological Process:	• insulin receptor signaling pathway • cAMP-mediated signaling • negative regulation of translational initiation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_004096 (mRNA)
NP_004087 (protein)

NM_010124 (mRNA)
NP_034254 (protein)

Location

Chr 10: 71.83 - 71.86 Mb

Chr 10: 60.83 - 60.85 Mb

Pubmed search

[1]

[2]

Eukaryotic translation initiation factor 4E binding protein 2, also known as EIF4EBP2, is a human gene.^[1]

[edit] References

^ Entrez Gene: EIF4EBP2 eukaryotic translation initiation factor 4E binding protein 2.

[edit] Further reading

Mader S, Lee H, Pause A, Sonenberg N (1995). "The translation initiation factor eIF-4E binds to a common motif shared by the translation factor eIF-4 gamma and the translational repressors 4E-binding proteins.". Mol. Cell. Biol. 15 (9): 4990–7. PMID 7651417.
Pause A, Belsham GJ, Gingras AC, et al. (1994). "Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5'-cap function.". Nature 371 (6500): 762–7. doi:10.1038/371762a0. PMID 7935836.
Lin TA, Lawrence JC (1997). "Control of the translational regulators PHAS-I and PHAS-II by insulin and cAMP in 3T3-L1 adipocytes.". J. Biol. Chem. 271 (47): 30199–204. PMID 8939971.
Tsukiyama-Kohara K, Vidal SM, Gingras AC, et al. (1997). "Tissue distribution, genomic structure, and chromosome mapping of mouse and human eukaryotic initiation factor 4E-binding proteins 1 and 2.". Genomics 38 (3): 353–63. doi:10.1006/geno.1996.0638. PMID 8975712.
Dilling MB, Germain GS, Dudkin L, et al. (2002). "4E-binding proteins, the suppressors of eukaryotic initiation factor 4E, are down-regulated in cells with acquired or intrinsic resistance to rapamycin.". J. Biol. Chem. 277 (16): 13907–17. doi:10.1074/jbc.M110782200. PMID 11847216.
Shenberger JS, Adams MH, Zimmer SG (2002). "Oxidant-induced hypertrophy of A549 cells is accompanied by alterations in eukaryotic translation initiation factor 4E and 4E-binding protein-1.". Am. J. Respir. Cell Mol. Biol. 27 (2): 250–6. PMID 12151318.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Ferguson G, Mothe-Satney I, Lawrence JC (2004). "Ser-64 and Ser-111 in PHAS-I are dispensable for insulin-stimulated dissociation from eIF4E.". J. Biol. Chem. 278 (48): 47459–65. doi:10.1074/jbc.M307949200. PMID 14507920.
Joshi B, Cameron A, Jagus R (2004). "Characterization of mammalian eIF4E-family members.". Eur. J. Biochem. 271 (11): 2189–203. doi:10.1111/j.1432-1033.2004.04149.x. PMID 15153109.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.