EIF4E2

From Wikipedia, the free encyclopedia

Eukaryotic translation initiation factor 4E family member 2

PDB rendering based on 2jgb.

Available structures: 2jgb, 2jgc

Identifiers

Symbol(s)

EIF4E2; 4E-LP; 4EHP; EIF4EL3; IF4e

External IDs

OMIM: 605895 MGI: 1914440 HomoloGene: 31268

Gene ontology
Molecular Function:	• RNA cap binding • translation initiation factor activity • protein binding
Cellular Component:	• cytoplasm
Biological Process:	• translational initiation • regulation of translation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_004846 (mRNA)
NP_004837 (protein)

NM_001039169 (mRNA)
NP_001034258 (protein)

Location

Chr 2: 233.12 - 233.16 Mb

Chr 1: 89.05 - 89.07 Mb

Pubmed search

[1]

[2]

Eukaryotic translation initiation factor 4E family member 2, also known as EIF4E2, is a human gene.^[1]

[edit] References

^ Entrez Gene: EIF4E2 eukaryotic translation initiation factor 4E family member 2.

[edit] Further reading

Rom E, Kim HC, Gingras AC, et al. (1998). "Cloning and characterization of 4EHP, a novel mammalian eIF4E-related cap-binding protein.". J. Biol. Chem. 273 (21): 13104–9. PMID 9582349.
Mao M, Fu G, Wu JS, et al. (1998). "Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning.". Proc. Natl. Acad. Sci. U.S.A. 95 (14): 8175–80. PMID 9653160.
Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.". Genome Res. 10 (10): 1546–60. PMID 11042152.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Tan NG, Ardley HC, Scott GB, et al. (2003). "Human homologue of ariadne promotes the ubiquitylation of translation initiation factor 4E homologous protein, 4EHP.". FEBS Lett. 554 (3): 501–4. PMID 14623119.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Tee AR, Tee JA, Blenis J (2004). "Characterizing the interaction of the mammalian eIF4E-related protein 4EHP with 4E-BP1.". FEBS Lett. 564 (1-2): 58–62. doi:10.1016/S0014-5793(04)00313-8. PMID 15094042.
Joshi B, Cameron A, Jagus R (2004). "Characterization of mammalian eIF4E-family members.". Eur. J. Biochem. 271 (11): 2189–203. doi:10.1111/j.1432-1033.2004.04149.x. PMID 15153109.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Okumura F, Zou W, Zhang DE (2007). "ISG15 modification of the eIF4E cognate 4EHP enhances cap structure-binding activity of 4EHP.". Genes Dev. 21 (3): 255–60. doi:10.1101/gad.1521607. PMID 17289916.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.
Rosettani P, Knapp S, Vismara MG, et al. (2007). "Structures of the human eIF4E homologous protein, h4EHP, in its m7GTP-bound and unliganded forms.". J. Mol. Biol. 368 (3): 691–705. doi:10.1016/j.jmb.2007.02.019. PMID 17368478.
Zuberek J, Kubacka D, Jablonowska A, et al. (2007). "Weak binding affinity of human 4EHP for mRNA cap analogs.". RNA 13 (5): 691–7. doi:10.1261/rna.453107. PMID 17369309.