EIF4B

From Wikipedia, the free encyclopedia

Eukaryotic translation initiation factor 4B

PDB rendering based on 1wi8.

Available structures: 1wi8

Identifiers

Symbol(s)

EIF4B; EIF-4B

External IDs

OMIM: 603928 MGI: 95304 HomoloGene: 83162

Gene ontology
Molecular Function:	• nucleotide binding • nucleic acid binding • RNA binding • translation initiation factor activity
Cellular Component:	• eukaryotic translation initiation factor 4F complex
Biological Process:	• translation • regulation of translational initiation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

n/a

Refseq

NM_001417 (mRNA)
NP_001408 (protein)

XM_001005455 (mRNA)
XP_001005455 (protein)

Location

Chr 12: 51.7 - 51.72 Mb

n/a

Pubmed search

[1]

[2]

Eukaryotic translation initiation factor 4B, also known as EIF4B, is a human gene.^[1]

[edit] References

^ Entrez Gene: EIF4B eukaryotic translation initiation factor 4B.

[edit] External links

Cap-dependent translation initiation from Nature Reviews Microbiology. A good image and overview of the function of initiation factors

[edit] Further reading

van Heugten HA, Kasperaitis MA, Thomas AA, Voorma HO (1991). "Evidence that eukaryotic initiation factor (eIF) 2 is a cap-binding protein that stimulates cap recognition by eIF-4B and eIF-4F.". J. Biol. Chem. 266 (11): 7279-84. PMID 2016328.
Milburn SC, Hershey JW, Davies MV, et al. (1990). "Cloning and expression of eukaryotic initiation factor 4B cDNA: sequence determination identifies a common RNA recognition motif.". EMBO J. 9 (9): 2783-90. PMID 2390971.
Howe JG, Hershey JW (1984). "Translational initiation factor and ribosome association with the cytoskeletal framework fraction from HeLa cells.". Cell 37 (1): 85-93. PMID 6722878.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171-4. PMID 8125298.
Méthot N, Pause A, Hershey JW, Sonenberg N (1994). "The translation initiation factor eIF-4B contains an RNA-binding region that is distinct and independent from its ribonucleoprotein consensus sequence.". Mol. Cell. Biol. 14 (4): 2307-16. PMID 8139536.
Naranda T, Strong WB, Menaya J, et al. (1994). "Two structural domains of initiation factor eIF-4B are involved in binding to RNA.". J. Biol. Chem. 269 (20): 14465-72. PMID 8182051.
Méthot N, Song MS, Sonenberg N (1996). "A region rich in aspartic acid, arginine, tyrosine, and glycine (DRYG) mediates eukaryotic initiation factor 4B (eIF4B) self-association and interaction with eIF3.". Mol. Cell. Biol. 16 (10): 5328-34. PMID 8816444.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149-56. PMID 9373149.
Richter NJ, Rogers GW, Hensold JO, Merrick WC (2000). "Further biochemical and kinetic characterization of human eukaryotic initiation factor 4H.". J. Biol. Chem. 274 (50): 35415-24. PMID 10585411.
Bushell M, Wood W, Clemens MJ, Morley SJ (2000). "Changes in integrity and association of eukaryotic protein synthesis initiation factors during apoptosis.". Eur. J. Biochem. 267 (4): 1083-91. PMID 10672017.
Bushell M, Wood W, Carpenter G, et al. (2001). "Disruption of the interaction of mammalian protein synthesis eukaryotic initiation factor 4B with the poly(A)-binding protein by caspase- and viral protease-mediated cleavages.". J. Biol. Chem. 276 (26): 23922-8. doi:10.1074/jbc.M100384200. PMID 11274152.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Fleming K, Ghuman J, Yuan X, et al. (2003). "Solution structure and RNA interactions of the RNA recognition motif from eukaryotic translation initiation factor 4B.". Biochemistry 42 (30): 8966-75. doi:10.1021/bi034506g. PMID 12885229.
Raught B, Peiretti F, Gingras AC, et al. (2005). "Phosphorylation of eucaryotic translation initiation factor 4B Ser422 is modulated by S6 kinases.". EMBO J. 23 (8): 1761-9. doi:10.1038/sj.emboj.7600193. PMID 15071500.
Doepker RC, Hsu WL, Saffran HA, Smiley JR (2004). "Herpes simplex virus virion host shutoff protein is stimulated by translation initiation factors eIF4B and eIF4H.". J. Virol. 78 (9): 4684-99. PMID 15078951.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130-5. doi:10.1073/pnas.0404720101. PMID 15302935.
Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.". Genome Res. 14 (9): 1711-8. doi:10.1101/gr.2435604. PMID 15342556.
Shahbazian D, Roux PP, Mieulet V, et al. (2006). "The mTOR/PI3K and MAPK pathways converge on eIF4B to control its phosphorylation and activity.". EMBO J. 25 (12): 2781-91. doi:10.1038/sj.emboj.7601166. PMID 16763566.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635-48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.