EIF3S6

From Wikipedia, the free encyclopedia

Eukaryotic translation initiation factor 3, subunit 6 48kDa

Identifiers

EIF3S6; EIF3-P48; INT6; eIF3-p46; eIF3e

External IDs

OMIM: 602210 MGI: 99257 HomoloGene: 1205

Gene ontology
Molecular Function:	• translation initiation factor activity • protein binding
Cellular Component:	• eukaryotic translation initiation factor 3 complex
Biological Process:	• translation • regulation of translational initiation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001568 (mRNA)
NP_001559 (protein)

NM_008388 (mRNA)
NP_032414 (protein)

Location

Chr 8: 109.28 - 109.33 Mb

Chr 15: 43.08 - 43.11 Mb

Pubmed search

[1]

[2]

Eukaryotic translation initiation factor 3, subunit 6 48kDa, also known as EIF3S6, is a human gene.^[1]

[edit] References

^ Entrez Gene: EIF3S6 Eukaryotic translation initiation factor 3, subunit 6 48kDa.

[edit] Further reading

{{PBB_Further_reading | citations =

Marchetti A, Buttitta F, Miyazaki S, Gallahan D, Smith GH, Callahan R. "Int-6, a highly conserved, widely expressed gene, is mutated by mouse mammary tumor virus in mammary preneoplasia.". J Virol. 69 (3): 1932–8.
Desbois C, Rousset R, Bantignies F, Jalinot P (1996). "Exclusion of Int-6 from PML nuclear bodies by binding to the HTLV–I Tax oncoprotein.". Science 273 (5277): 951–3. PMID 8688078.
Asano K, Kinzy TG, Merrick WC, Hershey JW (1997). "Conservation and diversity of eukaryotic translation initiation factor eIF3.". J. Biol. Chem. 272 (2): 1101–9. PMID 8995409.
Méthot N, Rom E, Olsen H, Sonenberg N (1997). "The human homologue of the yeast Prt1 protein is an integral part of the eukaryotic initiation factor 3 complex and interacts with p170.". J. Biol. Chem. 272 (2): 1110–6. PMID 8995410.
Asano K, Merrick WC, Hershey JW (1997). "The translation initiation factor eIF3-p48 subunit is encoded by int-6, a site of frequent integration by the mouse mammary tumor virus genome.". J. Biol. Chem. 272 (38): 23477–80. PMID 9295280.
Miyazaki S, Imatani A, Ballard L, et al. (1998). "The chromosome location of the human homolog of the mouse mammary tumor-associated gene INT6 and its status in human breast carcinomas.". Genomics 46 (1): 155–8. doi:10.1006/geno.1997.4996. PMID 9403073.
Block KL, Vornlocher HP, Hershey JW (1998). "Characterization of cDNAs encoding the p44 and p35 subunits of human translation initiation factor eIF3.". J. Biol. Chem. 273 (48): 31901–8. PMID 9822659.
Morris-Desbois C, Bochard V, Reynaud C, Jalinot P (1999). "Interaction between the Ret finger protein and the Int-6 gene product and co-localisation into nuclear bodies.". J. Cell. Sci. 112 ( Pt 19): 3331–42. PMID 10504338.
Guo J, Sen GC (2000). "Characterization of the interaction between the interferon-induced protein P56 and the Int6 protein encoded by a locus of insertion of the mouse mammary tumor virus.". J. Virol. 74 (4): 1892–9. PMID 10644362.
Guo J, Hui DJ, Merrick WC, Sen GC (2001). "A new pathway of translational regulation mediated by eukaryotic initiation factor 3.". EMBO J. 19 (24): 6891–9. doi:10.1093/emboj/19.24.6891. PMID 11118224.
Yen HC, Chang EC (2001). "Yin6, a fission yeast Int6 homolog, complexes with Moe1 and plays a role in chromosome segregation.". Proc. Natl. Acad. Sci. U.S.A. 97 (26): 14370–5. doi:10.1073/pnas.97.26.14370. PMID 11121040.
Morris-Desbois C, Réty S, Ferro M, et al. (2002). "The human protein HSPC021 interacts with Int-6 and is associated with eukaryotic translation initiation factor 3.". J. Biol. Chem. 276 (49): 45988–95. doi:10.1074/jbc.M104966200. PMID 11590142.
Hoareau Alves K, Bochard V, Réty S, Jalinot P (2002). "Association of the mammalian proto-oncoprotein Int-6 with the three protein complexes eIF3, COP9 signalosome and 26S proteasome.". FEBS Lett. 527 (1–3): 15–21. PMID 12220626.
Neuveut C, Jin DY, Semmes OJ, et al.. "Divergent Subcellular Locations of HTLV–I Tax and Int-6: A Contrast between in vitro Protein-Protein Binding and Intracellular Protein Colocalization." 4 (5): 229–234. PMID 12386384.
Huang GJ, Zhang ZQ, Jin DY (2002). "Stimulation of IKK-gamma oligomerization by the human T-cell leukemia virus oncoprotein Tax.". FEBS Lett. 531 (3): 494–8. PMID 12435599.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Yen HC, Gordon C, Chang EC (2003). "Schizosaccharomyces pombe Int6 and Ras homologs regulate cell division and mitotic fidelity via the proteasome.". Cell 112 (2): 207–17. PMID 12553909.
Mayeur GL, Fraser CS, Peiretti F, et al. (2003). "Characterization of eIF3k: a newly discovered subunit of mammalian translation initiation factor elF3.". Eur. J. Biochem. 270 (20): 4133–9. PMID 14519125.
Lehner B, Semple JI, Brown SE, et al. (2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region.". Genomics 83 (1): 153–67. PMID 14667819.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Watkins SJ, Norbury CJ (2004). "Cell cycle-related variation in subcellular localization of eIF3e/INT6 in human fibroblasts.". Cell Prolif. 37 (2): 149–60. doi:10.1111/j.1365–2184.2004.00305.x. PMID 15030549. .