EIF3K

From Wikipedia, the free encyclopedia

Eukaryotic translation initiation factor 3, subunit 12

PDB rendering based on 1rz4.

Available structures: 1rz4

Identifiers

Symbol(s)

EIF3S12; ARG134; HSPC029; M9; MSTP001; PLAC-24; PRO1474; PTD001; eIF3k

External IDs

OMIM: 609596 MGI: 1921080 HomoloGene: 8292

Gene ontology
Molecular Function:	• translation initiation factor activity
Cellular Component:	• nucleus
Biological Process:	• translational initiation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_013234 (mRNA)
NP_037366 (protein)

NM_028659 (mRNA)
NP_082935 (protein)

Location

Chr 19: 43.8 - 43.82 Mb

Chr 7: 28.68 - 28.69 Mb

Pubmed search

[1]

[2]

Eukaryotic translation initiation factor 3, subunit 12, also known as EIF3S12, is a human gene.^[1]

The 700-kD eukaryotic translation initiation factor-3 (eIF3) is the largest eIF and contains at least 12 subunits, including EIF2S12. eIF3 plays an essential role in translation by binding directly to the 40S ribosomal subunit and promoting formation of the 40S preinitiation complex (Mayeur et al., 2003).[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: EIF3S12 eukaryotic translation initiation factor 3, subunit 12.

[edit] Further reading

Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.". Genome Res. 10 (10): 1546-60. PMID 11042152.
Karki S, Ligon LA, DeSantis J, et al. (2002). "PLAC-24 is a cytoplasmic dynein-binding protein that is recruited to sites of cell-cell contact.". Mol. Biol. Cell 13 (5): 1722-34. doi:10.1091/mbc.02-02-0011. PMID 12006665.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Mayeur GL, Fraser CS, Peiretti F, et al. (2003). "Characterization of eIF3k: a newly discovered subunit of mammalian translation initiation factor elF3.". Eur. J. Biochem. 270 (20): 4133-9. PMID 14519125.
Wei Z, Zhang P, Zhou Z, et al. (2004). "Crystal structure of human eIF3k, the first structure of eIF3 subunits.". J. Biol. Chem. 279 (33): 34983-90. doi:10.1074/jbc.M405158200. PMID 15180986.
Shen X, Yang Y, Liu W, et al. (2004). "Identification of the p28 subunit of eukaryotic initiation factor 3(eIF3k) as a new interaction partner of cyclin D3.". FEBS Lett. 573 (1-3): 139-46. doi:10.1016/j.febslet.2004.07.071. PMID 15327989.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635-48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.