EIF3D

From Wikipedia, the free encyclopedia

Eukaryotic translation initiation factor 3, subunit 7 zeta, 66/67kDa

Identifiers

EIF3S7; MGC126526; MGC17258; eIF3-p66; eIF3-zeta; eIF3d

External IDs

OMIM: 603915 MGI: 1933181 HomoloGene: 2782

Gene ontology
Molecular Function:	• translation initiation factor activity • protein binding
Cellular Component:	• eukaryotic translation initiation factor 3 complex
Biological Process:	• regulation of translational initiation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_003753 (mRNA)
NP_003744 (protein)

NM_018749 (mRNA)
NP_061219 (protein)

Location

Chr 22: 35.24 - 35.26 Mb

Chr 15: 77.79 - 77.8 Mb

Pubmed search

[1]

[2]

Eukaryotic translation initiation factor 3, subunit 7 zeta, 66/67kDa, also known as EIF3S7, is a human gene.^[1]

Eukaryotic translation initiation factor-3 (eIF3), the largest of the eIFs, is a multiprotein complex composed of at least ten nonidentical subunits. The complex binds to the 40S ribosome and helps maintain the 40S and 60S ribosomal subunits in a dissociated state. It is also thought to play a role in the formation of the 40S initiation complex by interacting with the ternary complex of eIF2/GTP/methionyl-tRNA, and by promoting mRNA binding. The protein encoded by this gene is the major RNA binding subunit of the eIF3 complex.^[1]

[edit] References

^ ^a ^b Entrez Gene: EIF3S7 eukaryotic translation initiation factor 3, subunit 7 zeta, 66/67kDa.

[edit] Further reading

Asano K, Kinzy TG, Merrick WC, Hershey JW (1997). "Conservation and diversity of eukaryotic translation initiation factor eIF3.". J. Biol. Chem. 272 (2): 1101-9. PMID 8995409.
Méthot N, Rom E, Olsen H, Sonenberg N (1997). "The human homologue of the yeast Prt1 protein is an integral part of the eukaryotic initiation factor 3 complex and interacts with p170.". J. Biol. Chem. 272 (2): 1110-6. PMID 8995410.
Asano K, Vornlocher HP, Richter-Cook NJ, et al. (1997). "Structure of cDNAs encoding human eukaryotic initiation factor 3 subunits. Possible roles in RNA binding and macromolecular assembly.". J. Biol. Chem. 272 (43): 27042-52. PMID 9341143.
Block KL, Vornlocher HP, Hershey JW (1998). "Characterization of cDNAs encoding the p44 and p35 subunits of human translation initiation factor eIF3.". J. Biol. Chem. 273 (48): 31901-8. PMID 9822659.
Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22.". Nature 402 (6761): 489-95. doi:10.1038/990031. PMID 10591208.
Asano K, Shalev A, Phan L, et al. (2001). "Multiple roles for the C-terminal domain of eIF5 in translation initiation complex assembly and GTPase activation.". EMBO J. 20 (9): 2326-37. doi:10.1093/emboj/20.9.2326. PMID 11331597.
Hinz T, Flindt S, Marx A, et al. (2001). "Inhibition of protein synthesis by the T cell receptor-inducible human TDAG51 gene product.". Cell. Signal. 13 (5): 345-52. PMID 11369516.
Morris-Desbois C, Réty S, Ferro M, et al. (2002). "The human protein HSPC021 interacts with Int-6 and is associated with eukaryotic translation initiation factor 3.". J. Biol. Chem. 276 (49): 45988-95. doi:10.1074/jbc.M104966200. PMID 11590142.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Mayeur GL, Fraser CS, Peiretti F, et al. (2003). "Characterization of eIF3k: a newly discovered subunit of mammalian translation initiation factor elF3.". Eur. J. Biochem. 270 (20): 4133-9. PMID 14519125.
Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome.". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMID 15461802.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.". Nat. Biotechnol. 23 (1): 94-101. doi:10.1038/nbt1046. PMID 15592455.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.