EIF2C2

From Wikipedia, the free encyclopedia

Eukaryotic translation initiation factor 2C, 2

Identifiers

EIF2C2; AGO2; MGC3183; Q10

External IDs

OMIM: 606229 MGI: 2446632 HomoloGene: 81825

Gene ontology
Molecular Function:	• translation initiation factor activity • protein binding
Cellular Component:	• cellular_component
Biological Process:	• translation

Orthologs

Human

Mouse

Refseq

NM_012154 (mRNA)
NP_036286 (protein)

NM_153178 (mRNA)
NP_694818 (protein)

Location

Chr 8: 141.61 - 141.71 Mb

Chr 15: 72.93 - 72.97 Mb

Pubmed search

[1]

[2]

Eukaryotic translation initiation factor 2C, 2, also known as EIF2C2, is a human gene.^[1]

This gene encodes a member of the Argonaute family of proteins which play a role in RNA interference. The encoded protein is highly basic, and contains a PAZ domain and a PIWI domain. It may interact with dicer1 and play a role in short-interfering-RNA-mediated gene silencing.^[1]

[edit] References

^ ^a ^b Entrez Gene: EIF2C2 eukaryotic translation initiation factor 2C, 2.

[edit] Further reading

Carmell MA, Xuan Z, Zhang MQ, Hannon GJ (2002). "The Argonaute family: tentacles that reach into RNAi, developmental control, stem cell maintenance, and tumorigenesis.". Genes Dev. 16 (21): 2733-42. doi:10.1101/gad.1026102. PMID 12414724.
Koesters R, Adams V, Betts D, et al. (1999). "Human eukaryotic initiation factor EIF2C1 gene: cDNA sequence, genomic organization, localization to chromosomal bands 1p34-p35, and expression.". Genomics 61 (2): 210-8. doi:10.1006/geno.1999.5951. PMID 10534406.
Mourelatos Z, Dostie J, Paushkin S, et al. (2002). "miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs.". Genes Dev. 16 (6): 720-8. doi:10.1101/gad.974702. PMID 11914277.
Martinez J, Patkaniowska A, Urlaub H, et al. (2003). "Single-stranded antisense siRNAs guide target RNA cleavage in RNAi.". Cell 110 (5): 563-74. PMID 12230974.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Doi N, Zenno S, Ueda R, et al. (2003). "Short-interfering-RNA-mediated gene silencing in mammalian cells requires Dicer and eIF2C translation initiation factors.". Curr. Biol. 13 (1): 41-6. PMID 12526743.
Sasaki T, Shiohama A, Minoshima S, Shimizu N (2004). "Identification of eight members of the Argonaute family in the human genome small star, filled.". Genomics 82 (3): 323-30. PMID 12906857.
Tahbaz N, Kolb FA, Zhang H, et al. (2004). "Characterization of the interactions between mammalian PAZ PIWI domain proteins and Dicer.". EMBO Rep. 5 (2): 189-94. doi:10.1038/sj.embor.7400070. PMID 14749716.
Nelson PT, Hatzigeorgiou AG, Mourelatos Z (2004). "miRNP:mRNA association in polyribosomes in a human neuronal cell line.". RNA 10 (3): 387-94. PMID 14970384.
Liu J, Carmell MA, Rivas FV, et al. (2004). "Argonaute2 is the catalytic engine of mammalian RNAi.". Science 305 (5689): 1437-41. doi:10.1126/science.1102513. PMID 15284456.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Rivas FV, Tolia NH, Song JJ, et al. (2005). "Purified Argonaute2 and an siRNA form recombinant human RISC.". Nat. Struct. Mol. Biol. 12 (4): 340-9. doi:10.1038/nsmb918. PMID 15800637.
Sen GL, Blau HM (2005). "Argonaute 2/RISC resides in sites of mammalian mRNA decay known as cytoplasmic bodies.". Nat. Cell Biol. 7 (6): 633-6. doi:10.1038/ncb1265. PMID 15908945.
Liu J, Valencia-Sanchez MA, Hannon GJ, Parker R (2005). "MicroRNA-dependent localization of targeted mRNAs to mammalian P-bodies.". Nat. Cell Biol. 7 (7): 719-23. doi:10.1038/ncb1274. PMID 15937477.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514.
Kraynack BA, Baker BF (2006). "Small interfering RNAs containing full 2'-O-methylribonucleotide-modified sense strands display Argonaute2/eIF2C2-dependent activity.". RNA 12 (1): 163-76. doi:10.1261/rna.2150806. PMID 16301602.
Maniataki E, Mourelatos Z (2006). "A human, ATP-independent, RISC assembly machine fueled by pre-miRNA.". Genes Dev. 19 (24): 2979-90. doi:10.1101/gad.1384005. PMID 16357216.
Shi H, Tschudi C, Ullu E (2006). "Functional replacement of Trypanosoma brucei Argonaute by the human slicer Argonaute2.". RNA 12 (6): 943-7. doi:10.1261/rna.20806. PMID 16611939.
Wichroski MJ, Robb GB, Rana TM (2006). "Human retroviral host restriction factors APOBEC3G and APOBEC3F localize to mRNA processing bodies.". PLoS Pathog. 2 (5): e41. doi:10.1371/journal.ppat.0020041. PMID 16699599.