EIF2B5

From Wikipedia, the free encyclopedia

Eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa

Identifiers

EIF2B5; EIF-2B; CACH; CLE; EIF2Bepsilon; LVWM

External IDs

OMIM: 603945 MGI: 2446176 HomoloGene: 2903

Gene ontology
Molecular Function:	• translation initiation factor activity • guanyl-nucleotide exchange factor activity • protein binding • acyltransferase activity
Cellular Component:	• nucleus • cytoplasm • eukaryotic translation initiation factor 2B complex
Biological Process:	• ovarian follicle development • response to heat • response to glucose stimulus • astrocyte development • oligodendrocyte development • myelination • response to peptide hormone stimulus • positive regulation of translational initiation • cellular response to stimulus

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_003907 (mRNA)
NP_003898 (protein)

NM_172265 (mRNA)
NP_758469 (protein)

Location

Chr 3: 185.34 - 185.35 Mb

Chr 16: 20.41 - 20.42 Mb

Pubmed search

[1]

[2]

Eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa, also known as EIF2B5, is a human gene.^[1]

[edit] References

^ Entrez Gene: EIF2B5 eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa.

[edit] Further reading

Leegwater PA, Pronk JC, van der Knaap MS (2003). "Leukoencephalopathy with vanishing white matter: from magnetic resonance imaging pattern to five genes.". J. Child Neurol. 18 (9): 639–45. PMID 14572143.
Chaudhri MA, Crawford AC (1991). "Carbon determination in human teeth by activation with He-3 ions.". Biological trace element research 26-27: 521–7. PMID 1704758.
Welsh GI, Miyamoto S, Price NT, et al. (1996). "T-cell activation leads to rapid stimulation of translation initiation factor eIF2B and inactivation of glycogen synthase kinase-3.". J. Biol. Chem. 271 (19): 11410–3. PMID 8626696.
Asuru AI, Mellor H, Thomas NS, et al. (1996). "Cloning and characterization of cDNAs encoding the epsilon-subunit of eukaryotic initiation factor-2B from rabbit and human.". Biochim. Biophys. Acta 1307 (3): 309–17. PMID 8688466.
Kimball SR, Heinzinger NK, Horetsky RL, Jefferson LS (1998). "Identification of interprotein interactions between the subunits of eukaryotic initiation factors eIF2 and eIF2B.". J. Biol. Chem. 273 (5): 3039–44. PMID 9446619.
Welsh GI, Miller CM, Loughlin AJ, et al. (1998). "Regulation of eukaryotic initiation factor eIF2B: glycogen synthase kinase-3 phosphorylates a conserved serine which undergoes dephosphorylation in response to insulin.". FEBS Lett. 421 (2): 125–30. PMID 9468292.
Leegwater PA, Könst AA, Kuyt B, et al. (1999). "The gene for leukoencephalopathy with vanishing white matter is located on chromosome 3q27.". Am. J. Hum. Genet. 65 (3): 728–34. PMID 10441579.
Gomez E, Pavitt GD (2000). "Identification of domains and residues within the epsilon subunit of eukaryotic translation initiation factor 2B (eIF2Bepsilon) required for guanine nucleotide exchange reveals a novel activation function promoted by eIF2B complex formation.". Mol. Cell. Biol. 20 (11): 3965–76. PMID 10805739.
Anthony TG, Fabian JR, Kimball SR, Jefferson LS (2000). "Identification of domains within the epsilon-subunit of the translation initiation factor eIF2B that are necessary for guanine nucleotide exchange activity and eIF2B holoprotein formation.". Biochim. Biophys. Acta 1492 (1): 56–62. PMID 10858531.
Williams DD, Price NT, Loughlin AJ, Proud CG (2001). "Characterization of the mammalian initiation factor eIF2B complex as a GDP dissociation stimulator protein.". J. Biol. Chem. 276 (27): 24697–703. doi:10.1074/jbc.M011788200. PMID 11323413.
Wang X, Paulin FE, Campbell LE, et al. (2001). "Eukaryotic initiation factor 2B: identification of multiple phosphorylation sites in the epsilon-subunit and their functions in vivo.". EMBO J. 20 (16): 4349–59. doi:10.1093/emboj/20.16.4349. PMID 11500362.
Leegwater PA, Vermeulen G, Könst AA, et al. (2001). "Subunits of the translation initiation factor eIF2B are mutant in leukoencephalopathy with vanishing white matter.". Nat. Genet. 29 (4): 383–8. doi:10.1038/ng764. PMID 11704758.
Wang X, Janmaat M, Beugnet A, et al. (2002). "Evidence that the dephosphorylation of Ser(535) in the epsilon-subunit of eukaryotic initiation factor (eIF) 2B is insufficient for the activation of eIF2B by insulin.". Biochem. J. 367 (Pt 2): 475–81. doi:10.1042/BJ20020677. PMID 12133000.
Fogli A, Wong K, Eymard-Pierre E, et al. (2002). "Cree leukoencephalopathy and CACH/VWM disease are allelic at the EIF2B5 locus.". Ann. Neurol. 52 (4): 506–10. doi:10.1002/ana.10339. PMID 12325082.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Fogli A, Dionisi-Vici C, Deodato F, et al. (2003). "A severe variant of childhood ataxia with central hypomyelination/vanishing white matter leukoencephalopathy related to EIF21B5 mutation.". Neurology 59 (12): 1966–8. PMID 12499492.
Fogli A, Rodriguez D, Eymard-Pierre E, et al. (2003). "Ovarian failure related to eukaryotic initiation factor 2B mutations.". Am. J. Hum. Genet. 72 (6): 1544–50. PMID 12707859.
van der Knaap MS, van Berkel CG, Herms J, et al. (2004). "eIF2B-related disorders: antenatal onset and involvement of multiple organs.". Am. J. Hum. Genet. 73 (5): 1199–207. PMID 14566705.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.