EIF2B3

From Wikipedia, the free encyclopedia

Eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa

Identifiers

EIF2B3; EIF-2B; EIF2Bgamma

External IDs

OMIM: 606273 MGI: 1313286 HomoloGene: 7005

Gene ontology
Molecular Function:	• translation initiation factor activity • guanyl-nucleotide exchange factor activity • protein binding • nucleotidyltransferase activity
Cellular Component:	• cytoplasm • eukaryotic translation initiation factor 2B complex
Biological Process:	• translational initiation • biosynthetic process • response to heat • response to glucose stimulus • oligodendrocyte development • response to peptide hormone stimulus • cellular response to stimulus

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

Refseq

NM_020365 (mRNA)
NP_065098 (protein)

XM_131572 (mRNA)
XP_131572 (protein)

Location

Chr 1: 45.09 - 45.22 Mb

Chr 4: 116.52 - 116.57 Mb

Pubmed search

[1]

[2]

Eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa, also known as EIF2B3, is a human gene.^[1]

[edit] References

^ Entrez Gene: EIF2B3 eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa.

[edit] Further reading

Welsh GI, Miyamoto S, Price NT, et al. (1996). "T-cell activation leads to rapid stimulation of translation initiation factor eIF2B and inactivation of glycogen synthase kinase-3.". J. Biol. Chem. 271 (19): 11410-3. PMID 8626696.
Gomez E, Pavitt GD (2000). "Identification of domains and residues within the epsilon subunit of eukaryotic translation initiation factor 2B (eIF2Bepsilon) required for guanine nucleotide exchange reveals a novel activation function promoted by eIF2B complex formation.". Mol. Cell. Biol. 20 (11): 3965-76. PMID 10805739.
Anthony TG, Fabian JR, Kimball SR, Jefferson LS (2000). "Identification of domains within the epsilon-subunit of the translation initiation factor eIF2B that are necessary for guanine nucleotide exchange activity and eIF2B holoprotein formation.". Biochim. Biophys. Acta 1492 (1): 56-62. PMID 10858531.
Kruger M, Beger C, Li QX, et al. (2000). "Identification of eIF2Bgamma and eIF2gamma as cofactors of hepatitis C virus internal ribosome entry site-mediated translation using a functional genomics approach.". Proc. Natl. Acad. Sci. U.S.A. 97 (15): 8566-71. PMID 10900014.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788-95. PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422-35. doi:10.1101/gr.154701. PMID 11230166.
Williams DD, Price NT, Loughlin AJ, Proud CG (2001). "Characterization of the mammalian initiation factor eIF2B complex as a GDP dissociation stimulator protein.". J. Biol. Chem. 276 (27): 24697-703. doi:10.1074/jbc.M011788200. PMID 11323413.
van der Knaap MS, Leegwater PA, Könst AA, et al. (2002). "Mutations in each of the five subunits of translation initiation factor eIF2B can cause leukoencephalopathy with vanishing white matter.". Ann. Neurol. 51 (2): 264-70. PMID 11835386.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Fogli A, Dionisi-Vici C, Deodato F, et al. (2003). "A severe variant of childhood ataxia with central hypomyelination/vanishing white matter leukoencephalopathy related to EIF21B5 mutation.". Neurology 59 (12): 1966-8. PMID 12499492.
Fogli A, Rodriguez D, Eymard-Pierre E, et al. (2003). "Ovarian failure related to eukaryotic initiation factor 2B mutations.". Am. J. Hum. Genet. 72 (6): 1544-50. PMID 12707859.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Fogli A, Schiffmann R, Hugendubler L, et al. (2005). "Decreased guanine nucleotide exchange factor activity in eIF2B-mutated patients.". Eur. J. Hum. Genet. 12 (7): 561-6. doi:10.1038/sj.ejhg.5201189. PMID 15054402.
Li W, Wang X, Van Der Knaap MS, Proud CG (2004). "Mutations linked to leukoencephalopathy with vanishing white matter impair the function of the eukaryotic initiation factor 2B complex in diverse ways.". Mol. Cell. Biol. 24 (8): 3295-306. PMID 15060152.
Van Haren K, van der Voorn JP, Peterson DR, et al. (2004). "The life and death of oligodendrocytes in vanishing white matter disease.". J. Neuropathol. Exp. Neurol. 63 (6): 618-30. PMID 15217090.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline.". Genome Res. 14 (10B): 2136-44. doi:10.1101/gr.2576704. PMID 15489336.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514.
Suragani RN, Kamindla R, Ehtesham NZ, Ramaiah KV (2006). "Interaction of recombinant human eIF2 subunits with eIF2B and eIF2alpha kinases.". Biochem. Biophys. Res. Commun. 338 (4): 1766-72. doi:10.1016/j.bbrc.2005.10.150. PMID 16288713.
Mikami S, Masutani M, Sonenberg N, et al. (2006). "An efficient mammalian cell-free translation system supplemented with translation factors.". Protein Expr. Purif. 46 (2): 348-57. doi:10.1016/j.pep.2005.09.021. PMID 16289705.