EIF2A

From Wikipedia, the free encyclopedia

Eukaryotic translation initiation factor 2A, 65kDa

Identifiers

EIF2A; EIF-2A; CDA02; MST089; MSTP004; MSTP089

External IDs

OMIM: 609234 MGI: 1098684 HomoloGene: 5969

Gene ontology
Molecular Function:	• tRNA binding • translation initiation factor activity • ribosome binding
Cellular Component:	• cytoplasm • eukaryotic translation initiation factor 2 complex
Biological Process:	• regulation of translation • ribosome assembly

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_032025 (mRNA)
NP_114414 (protein)

NM_001005509 (mRNA)
NP_001005509 (protein)

Location

Chr 3: 151.75 - 151.78 Mb

Chr 3: 58.61 - 58.65 Mb

Pubmed search

[1]

[2]

Eukaryotic translation initiation factor 2A, 65kDa, also known as EIF2A, is a human gene.^[1]

EIF2A is a 65-kD protein that catalyzes the formation of puromycin-sensitive 80S preinitiation complexes (Zoll et al., 2002).[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: EIF2A eukaryotic translation initiation factor 2A, 65kDa.

[edit] Further reading

Merrick WC (1992). "Mechanism and regulation of eukaryotic protein synthesis.". Microbiol. Rev. 56 (2): 291-315. PMID 1620067.
Zoll WL, Horton LE, Komar AA, et al. (2002). "Characterization of mammalian eIF2A and identification of the yeast homolog.". J. Biol. Chem. 277 (40): 37079-87. doi:10.1074/jbc.M207109200. PMID 12133843.
Koumenis C, Naczki C, Koritzinsky M, et al. (2002). "Regulation of protein synthesis by hypoxia via activation of the endoplasmic reticulum kinase PERK and phosphorylation of the translation initiation factor eIF2alpha.". Mol. Cell. Biol. 22 (21): 7405-16. PMID 12370288.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Page AB, Owen CR, Kumar R, et al. (2003). "Persistent eIF2alpha(P) is colocalized with cytoplasmic cytochrome c in vulnerable hippocampal neurons after 4 hours of reperfusion following 10-minute complete brain ischemia.". Acta Neuropathol. 106 (1): 8-16. doi:10.1007/s00401-003-0693-2. PMID 12687390.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Ito T, Marintchev A, Wagner G (2005). "Solution structure of human initiation factor eIF2alpha reveals homology to the elongation factor eEF1B.". Structure 12 (9): 1693-704. doi:10.1016/j.str.2004.07.010. PMID 15341733.
Weiser DC, Sikes S, Li S, Shenolikar S (2005). "The inhibitor-1 C terminus facilitates hormonal regulation of cellular protein phosphatase-1: functional implications for inhibitor-1 isoforms.". J. Biol. Chem. 279 (47): 48904-14. doi:10.1074/jbc.M404416200. PMID 15345721.
Komar AA, Gross SR, Barth-Baus D, et al. (2005). "Novel characteristics of the biological properties of the yeast Saccharomyces cerevisiae eukaryotic initiation factor 2A.". J. Biol. Chem. 280 (16): 15601-11. doi:10.1074/jbc.M413728200. PMID 15718232.
Wang J, Laschinger C, Zhao XH, et al. (2005). "Mechanical force activates eIF-2alpha phospho-kinases in fibroblast.". Biochem. Biophys. Res. Commun. 330 (1): 123-30. doi:10.1016/j.bbrc.2005.02.140. PMID 15781241.
Gorrini C, Loreni F, Gandin V, et al. (2005). "Fibronectin controls cap-dependent translation through beta1 integrin and eukaryotic initiation factors 4 and 2 coordinated pathways.". Proc. Natl. Acad. Sci. U.S.A. 102 (26): 9200-5. doi:10.1073/pnas.0409513102. PMID 15961545.
Su Q, Wang S, Baltzis D, et al. (2006). "Tyrosine phosphorylation acts as a molecular switch to full-scale activation of the eIF2alpha RNA-dependent protein kinase.". Proc. Natl. Acad. Sci. U.S.A. 103 (1): 63-8. doi:10.1073/pnas.0508207103. PMID 16373505.
Squatrito M, Mancino M, Sala L, Draetta GF (2006). "Ebp1 is a dsRNA-binding protein associated with ribosomes that modulates eIF2alpha phosphorylation.". Biochem. Biophys. Res. Commun. 344 (3): 859-68. doi:10.1016/j.bbrc.2006.03.205. PMID 16631606.
Scheuner D, Patel R, Wang F, et al. (2006). "Double-stranded RNA-dependent protein kinase phosphorylation of the alpha-subunit of eukaryotic translation initiation factor 2 mediates apoptosis.". J. Biol. Chem. 281 (30): 21458-68. doi:10.1074/jbc.M603784200. PMID 16717090.
Mazroui R, Sukarieh R, Bordeleau ME, et al. (2007). "Inhibition of ribosome recruitment induces stress granule formation independently of eukaryotic initiation factor 2alpha phosphorylation.". Mol. Biol. Cell 17 (10): 4212-9. doi:10.1091/mbc.E06-04-0318. PMID 16870703.
Fribley AM, Evenchik B, Zeng Q, et al. (2006). "Proteasome inhibitor PS-341 induces apoptosis in cisplatin-resistant squamous cell carcinoma cells by induction of Noxa.". J. Biol. Chem. 281 (42): 31440-7. doi:10.1074/jbc.M604356200. PMID 16928686.
Fritsch RM, Schneider G, Saur D, et al. (2007). "Translational repression of MCL-1 couples stress-induced eIF2 alpha phosphorylation to mitochondrial apoptosis initiation.". J. Biol. Chem. 282 (31): 22551-62. doi:10.1074/jbc.M702673200. PMID 17553788.
Nayak R, Pintel DJ (2007). "Adeno-associated viruses can induce phosphorylation of eIF2alpha via PKR activation, which can be overcome by helper adenovirus type 5 virus-associated RNA.". J. Virol. 81 (21): 11908-16. doi:10.1128/JVI.01132-07. PMID 17715234.