EIF2AK4

From Wikipedia, the free encyclopedia

Eukaryotic translation initiation factor 2 alpha kinase 4

Identifiers

EIF2AK4; GCN2; KIAA1338

External IDs

OMIM: 609280 MGI: 1353427 HomoloGene: 40891

Gene ontology
Molecular Function:	• nucleotide binding • eukaryotic translation initiation factor 2alpha kinase activity • aminoacyl-tRNA ligase activity • ubiquitin-protein ligase activity • ATP binding • transferase activity
Cellular Component:	• intracellular • cytosolic ribosome (sensu Eukaryota)
Biological Process:	• tRNA aminoacylation for protein translation • regulation of translational initiation • protein amino acid phosphorylation • ubiquitin cycle

Orthologs

Human

Mouse

Refseq

NM_001013703 (mRNA)
NP_001013725 (protein)

NM_013719 (mRNA)
NP_038747 (protein)

Location

Chr 15: 38.01 - 38.12 Mb

Chr 2: 118.08 - 118.17 Mb

Pubmed search

[1]

[2]

Eukaryotic translation initiation factor 2 alpha kinase 4, also known as EIF2AK4, is a human gene.^[1]

EIF2AK4 belongs to a family of kinases that phosphorylate the alpha subunit of eukaryotic translation initiation factor-2 (EIF2S1; MIM 603907) to downregulate protein synthesis in response to varied cellular stresses (Berlanga et al., 1999).[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: EIF2AK4 eukaryotic translation initiation factor 2 alpha kinase 4.

[edit] Further reading

Berlanga JJ, Santoyo J, De Haro C (1999). "Characterization of a mammalian homolog of the GCN2 eukaryotic initiation factor 2alpha kinase.". Eur. J. Biochem. 265 (2): 754–62. PMID 10504407.
Nagase T, Kikuno R, Ishikawa KI, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 7 (1): 65–73. PMID 10718198.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Clark AG, Glanowski S, Nielsen R, et al. (2003). "Inferring nonneutral evolution from human-chimp-mouse orthologous gene trios.". Science 302 (5652): 1960–3. doi:10.1126/science.1088821. PMID 14671302.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells.". Science 307 (5715): 1621–5. doi:10.1126/science.1105776. PMID 15761153.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
Wissing J, Jänsch L, Nimtz M, et al. (2007). "Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry.". Mol. Cell Proteomics 6 (3): 537–47. doi:10.1074/mcp.T600062-MCP200. PMID 17192257.