EIF1

From Wikipedia, the free encyclopedia

Eukaryotic translation initiation factor 1

PDB rendering based on 2if1.

Available structures: 2if1

Identifiers

Symbol(s)

EIF1; EIF1A; A121; EIF-1; ISO1; SUI1

External IDs

MGI: 3643981 HomoloGene: 48375

Gene ontology
Molecular Function:	• translation initiation factor activity
Cellular Component:	• cytoplasm
Biological Process:	• regulation of translational initiation • response to stress

Orthologs

Human

Mouse

n/a

Refseq

NM_005801 (mRNA)
NP_005792 (protein)

XM_884867 (mRNA)
XP_889960 (protein)

Location

n/a

Chr 7: 84.71 - 84.71 Mb

Pubmed search

[1]

[2]

Eukaryotic translation initiation factor 1, also known as EIF1, is a human gene.^[1]

[edit] References

^ Entrez Gene: EIF1 eukaryotic translation initiation factor 1.

[edit] External links

Cap-dependent translation initiation from Nature Reviews Microbiology. A good image and overview of the function of initiation factors

[edit] Further reading

Fields C, Adams MD (1994). "Expressed sequence tags identify a human isolog of the suil translation initiation factor.". Biochem. Biophys. Res. Commun. 198 (1): 288–91. doi:10.1006/bbrc.1994.1040. PMID 7904817.
Hillier LD, Lennon G, Becker M, et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags.". Genome Res. 6 (9): 807–28. PMID 8889549.
Lian Z, Pan J, Liu J, et al. (1999). "The translation initiation factor, hu-Sui1 may be a target of hepatitis B X antigen in hepatocarcinogenesis.". Oncogene 18 (9): 1677–87. doi:10.1038/sj.onc.1202470. PMID 10208429.
Fletcher CM, Pestova TV, Hellen CU, Wagner G (1999). "Structure and interactions of the translation initiation factor eIF1.". EMBO J. 18 (9): 2631–7. doi:10.1093/emboj/18.9.2631. PMID 10228174.
Sheikh MS, Fernandez-Salas E, Yu M, et al. (1999). "Cloning and characterization of a human genotoxic and endoplasmic reticulum stress-inducible cDNA that encodes translation initiation factor 1(eIF1(A121/SUI1)).". J. Biol. Chem. 274 (23): 16487–93. PMID 10347211.
Chin LS, Singh SK, Wang Q, Murray SF (2000). "Identification of okadaic-acid-induced genes by mRNA differential display in glioma cells.". J. Biomed. Sci. 7 (2): 152–9. PMID 10754390.
Mendell JT, Medghalchi SM, Lake RG, et al. (2000). "Novel Upf2p orthologues suggest a functional link between translation initiation and nonsense surveillance complexes.". Mol. Cell. Biol. 20 (23): 8944–57. PMID 11073994.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455.