EI24

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Etoposide induced 2.4 mRNA
Identifiers
Symbol(s) EI24; PIG8; TP53I8
External IDs OMIM: 605170 MGI: 108090 HomoloGene: 3588
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 9538 13663
Ensembl ENSG00000149547 ENSMUSG00000062762
Uniprot O14681 Q3T9X1
Refseq NM_001007277 (mRNA)
NP_001007278 (protein)		 NM_007915 (mRNA)
NP_031941 (protein)
Location Chr 11: 124.94 - 124.96 Mb Chr 9: 36.53 - 36.55 Mb
Pubmed search [1] [2]

Etoposide induced 2.4 mRNA, also known as EI24, is a human gene.[1]

This gene has higher expression in p53-expressing cells than in control cells and is an immediate-early induction target of p53-mediated apoptosis. The protein encoded by this gene contains six putative transmembrane domains and may suppress cell growth by inducing apoptotic cell death through the caspase 9 and mitochondrial pathways. This gene is located on human chromosome 11q24, a region frequently altered in cancers. Alternative splicing results in two transcript variants encoding different isoforms.[1]

[edit] References

  1. ^ a b Entrez Gene: EI24 etoposide induced 2.4 mRNA.

[edit] Further reading

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171-4. PMID 8125298. 
  • Polyak K, Xia Y, Zweier JL, et al. (1997). "A model for p53-induced apoptosis.". Nature 389 (6648): 300-5. doi:10.1038/38525. PMID 9305847. 
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149-56. PMID 9373149. 
  • Gu Z, Flemington C, Chittenden T, Zambetti GP (2000). "ei24, a p53 response gene involved in growth suppression and apoptosis.". Mol. Cell. Biol. 20 (1): 233-41. PMID 10594026. 
  • Gu Z, Gilbert DJ, Valentine VA, et al. (2000). "The p53-inducible gene EI24/PIG8 localizes to human chromosome 11q23 and the proximal region of mouse chromosome 9.". Cytogenet. Cell Genet. 89 (3-4): 230-3. PMID 10965130. 
  • Burns TF, Bernhard EJ, El-Deiry WS (2001). "Tissue specific expression of p53 target genes suggests a key role for KILLER/DR5 in p53-dependent apoptosis in vivo.". Oncogene 20 (34): 4601-12. doi:10.1038/sj.onc.1204484. PMID 11498783. 
  • Gentile M, Ahnström M, Schön F, Wingren S (2002). "Candidate tumour suppressor genes at 11q23-q24 in breast cancer: evidence of alterations in PIG8, a gene involved in p53-induced apoptosis.". Oncogene 20 (53): 7753-60. doi:10.1038/sj.onc.1204993. PMID 11753653. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635-48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. 
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