EFNA4

From Wikipedia, the free encyclopedia

Ephrin-A4

Identifiers

EFNA4; EFL4; EPLG4; LERK4; MGC125826

External IDs

OMIM: 601380 MGI: 106643 HomoloGene: 3830

Gene ontology
Molecular Function:	• transmembrane-ephrin receptor activity • GPI anchor binding
Cellular Component:	• integral to plasma membrane • membrane
Biological Process:	• cell-cell signaling

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_005227 (mRNA)
NP_005218 (protein)

NM_007910 (mRNA)
NP_031936 (protein)

Location

Chr 1: 153.3 - 153.31 Mb

Chr 3: 89.42 - 89.42 Mb

Pubmed search

[1]

[2]

Ephrin-A4, also known as EFNA4, is a human gene.^[1]

This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNA class ephrin. Three transcript variants that encode distinct proteins have been identified.^[1]

[edit] References

^ ^a ^b Entrez Gene: EFNA4 ephrin-A4.

[edit] Further reading

Flanagan JG, Vanderhaeghen P (1998). "The ephrins and Eph receptors in neural development.". Annu. Rev. Neurosci. 21: 309-45. doi:10.1146/annurev.neuro.21.1.309. PMID 9530499.
Zhou R (1998). "The Eph family receptors and ligands.". Pharmacol. Ther. 77 (3): 151-81. PMID 9576626.
Holder N, Klein R (1999). "Eph receptors and ephrins: effectors of morphogenesis.". Development 126 (10): 2033-44. PMID 10207129.
Wilkinson DG (2000). "Eph receptors and ephrins: regulators of guidance and assembly.". Int. Rev. Cytol. 196: 177-244. PMID 10730216.
Xu Q, Mellitzer G, Wilkinson DG (2001). "Roles of Eph receptors and ephrins in segmental patterning.". Philos. Trans. R. Soc. Lond., B, Biol. Sci. 355 (1399): 993-1002. doi:10.1098/rstb.2000.0635. PMID 11128993.
Wilkinson DG (2001). "Multiple roles of EPH receptors and ephrins in neural development.". Nat. Rev. Neurosci. 2 (3): 155-64. PMID 11256076.
Kozlosky CJ, Maraskovsky E, McGrew JT, et al. (1995). "Ligands for the receptor tyrosine kinases hek and elk: isolation of cDNAs encoding a family of proteins.". Oncogene 10 (2): 299-306. PMID 7838529.
Cerretti DP, Lyman SD, Kozlosky CJ, et al. (1997). "The genes encoding the eph-related receptor tyrosine kinase ligands LERK-1 (EPLG1, Epl1), LERK-3 (EPLG3, Epl3), and LERK-4 (EPLG4, Epl4) are clustered on human chromosome 1 and mouse chromosome 3.". Genomics 33 (2): 277-82. doi:10.1006/geno.1996.0192. PMID 8660976.
Gale NW, Holland SJ, Valenzuela DM, et al. (1996). "Eph receptors and ligands comprise two major specificity subclasses and are reciprocally compartmentalized during embryogenesis.". Neuron 17 (1): 9-19. PMID 8755474.
"Unified nomenclature for Eph family receptors and their ligands, the ephrins. Eph Nomenclature Committee." (1997). Cell 90 (3): 403-4. PMID 9267020.
Janis LS, Cassidy RM, Kromer LF (1999). "Ephrin-A binding and EphA receptor expression delineate the matrix compartment of the striatum.". J. Neurosci. 19 (12): 4962-71. PMID 10366629.
Choi S, Jeong J, Kim T, Park S (2000). "Characterization of ephrin-A1 and ephrin-A4 as ligands for the EphA8 receptor protein tyrosine kinase.". Mol. Cells 9 (4): 440-5. PMID 10515610.
Aasheim HC, Munthe E, Funderud S, et al. (2000). "A splice variant of human ephrin-A4 encodes a soluble molecule that is secreted by activated human B lymphocytes.". Blood 95 (1): 221-30. PMID 10607706.
Munthe E, Aasheim HC (2002). "Characterization of the human ephrin-A4 promoter.". Biochem. J. 366 (Pt 2): 447-58. doi:10.1042/BJ20011693. PMID 12030849.