EFNA2

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Ephrin-A2
Identifiers
Symbol(s) EFNA2; ELF-1; EPLG6; HEK7-L; LERK6
External IDs OMIM: 602756 MGI: 102707 HomoloGene: 1075
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 1943 13637
Ensembl ENSG00000099617 ENSMUSG00000003070
Uniprot O43921 Q3USB4
Refseq NM_001405 (mRNA)
NP_001396 (protein)		 NM_007909 (mRNA)
NP_031935 (protein)
Location Chr 19: 1.24 - 1.25 Mb Chr 10: 79.58 - 79.59 Mb
Pubmed search [1] [2]

Ephrin-A2, also known as EFNA2, is a human gene.[1]

This gene encodes a member of the ephrin family. The protein is composed of a signal sequence, a receptor-binding region, a spacer region, and a hydrophobic region. The EPH and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. Posttranslational modifications determine whether this protein localizes to the nucleus or the cytoplasm.[1]

[edit] References

  1. ^ a b Entrez Gene: EFNA2 ephrin-A2.

[edit] Further reading

  • Flanagan JG, Vanderhaeghen P (1998). "The ephrins and Eph receptors in neural development.". Annu. Rev. Neurosci. 21: 309-45. doi:10.1146/annurev.neuro.21.1.309. PMID 9530499. 
  • Zhou R (1998). "The Eph family receptors and ligands.". Pharmacol. Ther. 77 (3): 151-81. PMID 9576626. 
  • Holder N, Klein R (1999). "Eph receptors and ephrins: effectors of morphogenesis.". Development 126 (10): 2033-44. PMID 10207129. 
  • Wilkinson DG (2000). "Eph receptors and ephrins: regulators of guidance and assembly.". Int. Rev. Cytol. 196: 177-244. PMID 10730216. 
  • Xu Q, Mellitzer G, Wilkinson DG (2001). "Roles of Eph receptors and ephrins in segmental patterning.". Philos. Trans. R. Soc. Lond., B, Biol. Sci. 355 (1399): 993-1002. doi:10.1098/rstb.2000.0635. PMID 11128993. 
  • Wilkinson DG (2001). "Multiple roles of EPH receptors and ephrins in neural development.". Nat. Rev. Neurosci. 2 (3): 155-64. PMID 11256076. 
  • Gale NW, Holland SJ, Valenzuela DM, et al. (1996). "Eph receptors and ligands comprise two major specificity subclasses and are reciprocally compartmentalized during embryogenesis.". Neuron 17 (1): 9-19. PMID 8755474. 
  • "Unified nomenclature for Eph family receptors and their ligands, the ephrins. Eph Nomenclature Committee." (1997). Cell 90 (3): 403-4. PMID 9267020. 
  • Cerretti DP, Nelson N (1998). "Characterization of the genes for mouse LERK-3/Ephrin-A3 (Epl3), mouse LERK-4/Ephrin-A4 (Epl4), and human LERK-6/Ephrin-A2 (EPLG6): conservation of intron/exon structure.". Genomics 47 (1): 131-5. doi:10.1006/geno.1997.5088. PMID 9465306. 
  • Ciossek T, Monschau B, Kremoser C, et al. (1998). "Eph receptor-ligand interactions are necessary for guidance of retinal ganglion cell axons in vitro.". Eur. J. Neurosci. 10 (5): 1574-80. PMID 9751130. 
  • Aasheim HC, Pedeutour F, Grosgeorge J, Logtenberg T (1998). "Cloning, chromosal mapping, and tissue expression of the gene encoding the human Eph-family kinase ligand ephrin-A2.". Biochem. Biophys. Res. Commun. 252 (2): 378-82. doi:10.1006/bbrc.1998.9618. PMID 9826538. 
  • Gerlai R, Shinsky N, Shih A, et al. (1999). "Regulation of learning by EphA receptors: a protein targeting study.". J. Neurosci. 19 (21): 9538-49. PMID 10531456. 
  • Hattori M, Osterfield M, Flanagan JG (2000). "Regulated cleavage of a contact-mediated axon repellent.". Science 289 (5483): 1360-5. PMID 10958785. 
  • Rodger J, Lindsey KA, Leaver SG, et al. (2002). "Expression of ephrin-A2 in the superior colliculus and EphA5 in the retina following optic nerve section in adult rat.". Eur. J. Neurosci. 14 (12): 1929-36. PMID 11860487. 
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