Edward Tobinick

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Edward Lewis Tobinick is an American physician currently in full-time private practice in Los Angeles, California and he is an Assistant Clinical Professor of Medicine at the David Geffen School of Medicine at UCLA.[1] Dr. Tobinick is co-author of the recent case report documenting rapid clinical improvement in a patient with Alzheimer's disease following perispinal administration of etanercept[2] which has been received with considerable interest[3][4].

Tobinick has been issued patents for methods of perispinal administration, of certain recombinant DNA-derived (biologic) therapeutics including the TNF receptor fusion protein etanercept, for the treatment of certain neurologic disorders with widespread unmet medical need, including Alzheimer's disease; pain due to cancer metastasis to bone; severe, intractable, intervertebral disc-related pain and radiculopathy (including sciatica); and myasthenia gravis.[5] In addition, he originated the concept of the potential utility of etanercept, alone or in combination with oseltamivir for treatment of influenza (U.S. patent 6,419,934, filed September 5, 2000 [1]). For these novel treatment methods he has been issued multiple U.S. patents, including 6,015,557 (Tumor necrosis factor antagonists for the treatment of neurological disorders) [2]; 6,177,077 [3]; 6,419,934 [4]; and 6,982,089 [5]. In general, his concepts represent emerging therapeutic strategies supported by small pilot studies and expert reviews. (see 2007 Citations, below). [6]

Tobinick earned his M.D. from the UC San Diego School of Medicine in 1977.

Contents

Publications

  • Tobinick E, Gross H. (2008). "Rapid cognitive improvement in Alzheimer's disease following perispinal etanercept administration". Journal of Neuroinflammation 5 (2): 2. doi:10.1186/1742-2094-5-2. PMID 18184433. 
  • Tobinick E, Gross H, Weinberger A, Cohen H. (2006). "TNF-alpha modulation for treatment of Alzheimer's disease: a 6-month pilot study". Medscape General Medicine 8 (2): 25f. PMID 16926764. 
  • Tobinick E. (2006). "The Cerebrospinal Venous System: Anatomy, Physiology, and Clinical Implications". Medscape General Medicine 8 (1): 53f. PMID 16915183. 
  • Tobinick E, Davoodifar S. (2004). "Efficacy of etanercept delivered by perispinal administration for chronic back and/or neck disc-related pain: a study of clinical observations in 143 patients". Curr Med Res Opin 20 (7): 1075–85. doi:10.1185/030079903125004286. PMID 15265252. 
  • Tobinick E, Britschgi-Davoodifar S. (2003). "Perispinal TNF-alpha inhibition for discogenic pain.". Clinical Therapeutics 25 (4): 1211–18. PMID 12809967. 
  • Tobinick E. (2003). "Targeted etanercept for discogenic neck pain: uncontrolled, open-label results in two adults.". Swiss Med Wkly 133 (11-12): 170–177. PMID 12715286. 
  • Tobinick E. (2003 (August)). "Targeted etanercept for treatment-refractory pain due to bone metastasis: two case reports.". Clinical Therapeutics 25 (8): 2279–88. doi:10.1016/S0149-2918(03)80219-9. PMID 14512134. 
  • Tobinick E. (2004). "TNF-alpha inhibition for potential therapeutic modulation of SARS coronavirus infection.". Curr Med Res Opin 20 (1): 39–40. doi:10.1185/030079903125002757. PMID 14741070. 
  • Tobinick, Edward; Richard Usatine, Ronald Moy, Daniel Siegel (1998). Skin Surgery: A Practical Guide. St. Louis: Mosby. ISBN 0-8151-7362-8. 

Citations

In 2007 the following scientific publications have cited Tobinick publications: Scientific Articles:

  • 1. Uceyler N, Sommer C. Cytokine-induced Pain: Basic Science and Clinical Implications. Reviews in Analgesia 2007;9(2):87-103.
  • 2. Tweedie D, Sambamurti K, Greig NH. Drug Design & Development Section, Laboratory of Neurosciences, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, US. TNF-alpha Inhibition as a Treatment Strategy for Neurodegenerative Disorders: New Drug Candidates and Targets. Curr Alzheimer Res. 2007 Sep;4(4):375-8.
  • 2. Tubbs RS, Hansasuta A, Loukas M, Louis RG, Jr., Shoja MM, Salter EG, et al. The basilar venous plexus. Clin Anat 2007.
  • 3. Saxena AK, Kumar S. Management strategies for pain in breast carcinoma patients: current opinions and future perspectives. Pain Pract 2007;7(2):163-77.
  • 4. Owlia MB, Salimzadeh A, Alishiri G, Haghighi A. Comparison of two doses of corticosteroid in epidural steroid injection for lumbar radicular pain. Singapore Med J 2007;48(3):241-5.
  • 5. Munoz L, Ralay Ranaivo H, Roy SM, Hu W, Craft JM, McNamara LK, et al. A novel p38alpha MAPK inhibitor suppresses brain proinflammatory cytokine up-regulation and attenuates synaptic dysfunction and behavioral deficits in an Alzheimer's disease mouse model. J Neuroinflammation 2007;4(1):21.
  • 6. Hu W, Ranaivo HR, Roy SM, Behanna HA, Wing LK, Munoz L, et al. Development of a novel therapeutic suppressor of brain proinflammatory cytokine up-regulation that attenuates synaptic dysfunction and behavioral deficits. Bioorg Med Chem Lett 2007;17(2):414-8.
  • 7. Le Maitre CL, Hoyland JA, Freemont AJ. Catabolic cytokine expression in degenerate and herniated human intervertebral discs: IL-1beta and TNFalpha expression profile. Arthritis Res Ther. 2007 Aug 9;9(4):R77.

Hardcover/ Bound Texts:

  • 1. Neuroinflammation in Neuronal Death and Repair, Volume 82 (International Review of Neurobiology.) G. Bagetta, editor (Hardcover - Jul 16, 2007) Amsterdam ; Boston : Elsevier Academic Press ©2007. ISBN 9780123739896 0123739896.
  • 2. Interactions Between Neurons and Glia in Aging and Disease by Joao Malva, Ana Cristina Rego, Rodrigo Cunha, and Catarina Oliveira (Eds.) (Hardcover - Aug 22, 2007). 2007, Approx. 535 p., Hardcover ISBN 978-0-387-70829-4 New York ; London : Springer, 2007.
  • 3. Cytokines in the Genesis and Treatment of Cancer (Cancer Drug Discovery and Development) by Michael A. Caligiuri and Michael T. Lotze (Hardcover - April 20, 2007) Totowa, N.J. : Humana Press ©2007. ISBN 9780896038202 0896038203 9781597454551 1597454559.
  • 4. Chapter 10: Anti-TNF-alpha antibody and cancer cachexia, The ASCRS Textbook of Colon and Rectal Surgery by J.M. Church, J. Garcia-Aguilar, P.L. Roberts, and T.J. Saclarides; New York : Springer ©2007. ISBN 9780387248462 0387248463.
  • 5. Spinal Reconstruction: Clinical Examples of Applied Basic Science, Biomechanics and Engineering by Kai-Uwe Lewandrowski, Michael J. Yaszemski, Iain Kalfas, and Paul Park (Hardcover - Feb 12, 2007) New York : Informa Healthcare ©2007. ISBN 9780849398155 0849398150.
  • 6. Olesen J, Jensen T. From Basic Pain Mechanisms to Headache. Oxford University Press 2007.
  • 7. Neuroimmunology: The Immune System and Alzheimers, in the 2007 Progress Report on Brain Research, Dana Alliance for Brain Initiatives, Dana Press, New York ©2007.

References

  1. ^ UCLA Headlines Jan. 11, 2008 / UCLA Newsroom
  2. ^ Journal of Neuroinflammation | Full text | Rapid cognitive improvement in Alzheimer's disease following perispinal etanercept administration
  3. ^ Journal of Neuroinflammation | Full text | Perispinal etanercept: Potential as an Alzheimer therapeutic
  4. ^ UCLA Headlines Jan. 11, 2008 / UCLA Newsroom
  5. ^ United States Patent 6,423,321
  6. ^ Tobinick's private practice
  • Rosenberg P. (2006). "Editorial: Cytokine inhibition for treatment of Alzheimer's Disease". MedGenMed Neurology & Neurosurgery 8 (2): 1.  link

External links