EDF1

From Wikipedia, the free encyclopedia

Endothelial differentiation-related factor 1

PDB rendering based on 1x57.

Available structures: 1x57

Identifiers

Symbol(s)

EDF1; EDF-1; MBF1; MGC9058

External IDs

OMIM: 605107 MGI: 1891227 HomoloGene: 2809

Gene ontology
Molecular Function:	• transcription factor activity • transcription coactivator activity • histone acetyltransferase activity • calmodulin binding • methyltransferase activity • sequence-specific DNA binding
Cellular Component:	• intracellular • nucleus • transcription factor TFIID complex • cytoplasm
Biological Process:	• regulation of transcription, DNA-dependent • multicellular organismal development • regulation of lipid metabolic process • positive regulation of DNA binding • endothelial cell differentiation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

n/a

Refseq

NM_003792 (mRNA)
NP_003783 (protein)

NM_021519 (mRNA)
NP_067494 (protein)

Location

Chr 9: 138.88 - 138.88 Mb

n/a

Pubmed search

[1]

[2]

Endothelial differentiation-related factor 1, also known as EDF1, is a human gene.^[1]

This gene encodes a protein that may regulate endothelial cell differentiation. It has been postulated that the protein functions as a bridging molecule that interconnects regulatory proteins and the basal transcriptional machinery, thereby modulating the transcription of genes involved in endothelial differentiation. This protein has also been found to act as a transcriptional coactivator by interconnecting the general transcription factor TATA element-binding protein (TBP) and gene-specific activators. Two alternatively spliced transcripts which encode distinct proteins have been found for this gene.^[1]

[edit] References

^ ^a ^b Entrez Gene: EDF1 endothelial differentiation-related factor 1.

[edit] Further reading

Li FQ, Ueda H, Hirose S (1994). "Mediators of activation of fushi tarazu gene transcription by BmFTZ-F1.". Mol. Cell. Biol. 14 (5): 3013–21. PMID 8164657.
Dragoni I, Mariotti M, Consalez GG, et al. (1998). "EDF-1, a novel gene product down-regulated in human endothelial cell differentiation.". J. Biol. Chem. 273 (47): 31119–24. PMID 9813014.
Ozaki J, Takemaru KI, Ikegami T, et al. (1999). "Identification of the core domain and the secondary structure of the transcriptional coactivator MBF1.". Genes Cells 4 (7): 415–24. PMID 10469174.
Kabe Y, Goto M, Shima D, et al. (1999). "The role of human MBF1 as a transcriptional coactivator.". J. Biol. Chem. 274 (48): 34196–202. PMID 10567391.
Mariotti M, De Benedictis L, Avon E, Maier JA (2000). "Interaction between endothelial differentiation-related factor-1 and calmodulin in vitro and in vivo.". J. Biol. Chem. 275 (31): 24047–51. doi:10.1074/jbc.M001928200. PMID 10816571.
Brendel C, Gelman L, Auwerx J (2003). "Multiprotein bridging factor-1 (MBF-1) is a cofactor for nuclear receptors that regulate lipid metabolism.". Mol. Endocrinol. 16 (6): 1367–77. PMID 12040021.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Ballabio E, Mariotti M, De Benedictis L, Maier JA (2004). "The dual role of endothelial differentiation-related factor-1 in the cytosol and nucleus: modulation by protein kinase A.". Cell. Mol. Life Sci. 61 (9): 1069–74. doi:10.1007/s00018-004-4016-0. PMID 15112053.
Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9.". Nature 429 (6990): 369–74. doi:10.1038/nature02465. PMID 15164053.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Bolognese F, Pitarque-Martì M, Lo Cicero V, et al. (2006). "Characterization of the human EDF-1 minimal promoter: involvement of NFY and Sp1 in the regulation of basal transcription.". Gene 374: 87–95. doi:10.1016/j.gene.2006.01.030. PMID 16567061.