EDC3

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Enhancer of mRNA decapping 3 homolog (S. cerevisiae)
Identifiers
Symbol(s) EDC3; FLJ21128; FLJ31777; LSM16; YJDC
External IDs OMIM: 609842 MGI: 2142951 HomoloGene: 11827
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 80153 353190
Ensembl ENSG00000179151 ENSMUSG00000038957
Uniprot Q96F86 A0ELI5
Refseq NM_025083 (mRNA)
NP_079359 (protein)		 NM_153799 (mRNA)
NP_722494 (protein)
Location Chr 15: 72.71 - 72.78 Mb Chr 9: 57.51 - 57.55 Mb
Pubmed search [1] [2]

Enhancer of mRNA decapping 3 homolog (S. cerevisiae), also known as EDC3, is a human gene.[1]

EDC3 is associated with an mRNA-decapping complex required for removal of the 5-prime cap from mRNA prior to its degradation from the 5-prime end (Fenger-Gron et al., 2005).[supplied by OMIM][1]

[edit] References

  1. ^ a b Entrez Gene: EDC3 enhancer of mRNA decapping 3 homolog (S. cerevisiae).

[edit] Further reading

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171-4. PMID 8125298. 
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149-56. PMID 9373149. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039. 
  • Albrecht M, Lengauer T (2004). "Novel Sm-like proteins with long C-terminal tails and associated methyltransferases.". FEBS Lett. 569 (1-3): 18-26. doi:10.1016/j.febslet.2004.03.126. PMID 15225602. 
  • Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization.". Curr. Biol. 14 (16): 1436-50. doi:10.1016/j.cub.2004.07.051. PMID 15324660. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Wan D, Gong Y, Qin W, et al. (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression.". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724-9. doi:10.1073/pnas.0404089101. PMID 15498874. 
  • Fenger-Grøn M, Fillman C, Norrild B, Lykke-Andersen J (2006). "Multiple processing body factors and the ARE binding protein TTP activate mRNA decapping.". Mol. Cell 20 (6): 905-15. doi:10.1016/j.molcel.2005.10.031. PMID 16364915. 
  • Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization.". Nat. Biotechnol. 24 (10): 1285-92. doi:10.1038/nbt1240. PMID 16964243. 
  • Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931. 
  • Tritschler F, Eulalio A, Truffault V, et al. (2007). "A divergent Sm fold in EDC3 proteins mediates DCP1 binding and P-body targeting.". Mol. Cell. Biol. 27 (24): 8600-11. doi:10.1128/MCB.01506-07. PMID 17923697. 
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