ECHS1

From Wikipedia, the free encyclopedia

Enoyl Coenzyme A hydratase, short chain, 1, mitochondrial

PDB rendering based on 1dub.

Available structures: 1dub, 2dub, 2hw5

Identifiers

Symbol(s)

ECHS1; SCEH

External IDs

OMIM: 602292 MGI: 2136460 HomoloGene: 3018

Gene ontology
Molecular Function:	• enoyl-CoA hydratase activity • lyase activity
Cellular Component:	• mitochondrion
Biological Process:	• generation of precursor metabolites and energy • lipid metabolic process • fatty acid metabolic process • fatty acid beta-oxidation • metabolic process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_004092 (mRNA)
NP_004083 (protein)

NM_053119 (mRNA)
NP_444349 (protein)

Location

Chr 10: 135.03 - 135.04 Mb

Chr 7: 139.96 - 139.97 Mb

Pubmed search

[1]

[2]

Enoyl Coenzyme A hydratase, short chain, 1, mitochondrial, also known as ECHS1, is a human gene.^[1]

The protein encoded by this gene functions in the second step of the mitochondrial fatty acid beta-oxidation pathway. It catalyzes the hydration of 2-trans-enoyl-coenzyme A (CoA) intermediates to L-3-hydroxyacyl-CoAs. The gene product is a member of the hydratase/isomerase superfamily. It localizes to the mitochondrial matrix. Transcript variants utilizing alternative transcription initiation sites have been described in the literature.^[1]

[edit] References

^ ^a ^b Entrez Gene: ECHS1 enoyl Coenzyme A hydratase, short chain, 1, mitochondrial.

[edit] Further reading

Hochstrasser DF, Frutiger S, Paquet N, et al. (1993). "Human liver protein map: a reference database established by microsequencing and gel comparison.". Electrophoresis 13 (12): 992–1001. PMID 1286669.
Dawson SJ, White LA (1992). "Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin.". J. Infect. 24 (3): 317–20. PMID 1602151.
Li J, Norwood DL, Mao LF, Schulz H (1991). "Mitochondrial metabolism of valproic acid.". Biochemistry 30 (2): 388–94. PMID 1988037.
Jackson S, Schaefer J, Middleton B, Turnbull DM (1995). "Characterisation of a novel enzyme of human fatty acid beta-oxidation: a matrix-associated, mitochondrial 2-enoyl-CoA hydratase.". Biochem. Biophys. Res. Commun. 214 (1): 247–53. PMID 7669045.
Kanazawa M, Ohtake A, Abe H, et al. (1994). "Molecular cloning and sequence analysis of the cDNA for human mitochondrial short-chain enoyl-CoA hydratase.". Enzyme Protein 47 (1): 9–13. PMID 8012501.
Janssen U, Davis EM, Le Beau MM, Stoffel W (1997). "Human mitochondrial enoyl-CoA hydratase gene (ECHS1): structural organization and assignment to chromosome 10q26.2-q26.3.". Genomics 40 (3): 470–5. doi:10.1006/geno.1996.4597. PMID 9073515.
Hubbard MJ, McHugh NJ (2001). "Human ERp29: isolation, primary structural characterisation and two-dimensional gel mapping.". Electrophoresis 21 (17): 3785–96. doi:10.1002/1522-2683(200011)21:17<3785::AID-ELPS3785>3.0.CO;2-2. PMID 11271497.
Jiang LQ, Wen SJ, Wang HY, Chen LY (2003). "Screening the proteins that interact with calpain in a human heart cDNA library using a yeast two-hybrid system.". Hypertens. Res. 25 (4): 647–52. PMID 12358155.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10.". Nature 429 (6990): 375–81. doi:10.1038/nature02462. PMID 15164054.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Bruneel A, Labas V, Mailloux A, et al. (2006). "Proteomics of human umbilical vein endothelial cells applied to etoposide-induced apoptosis.". Proteomics 5 (15): 3876–84. doi:10.1002/pmic.200401239. PMID 16130169.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.
Takahashi M, Watari E, Shinya E, et al. (2007). "Suppression of virus replication via down-modulation of mitochondrial short chain enoyl-CoA hydratase in human glioblastoma cells.". Antiviral Res. 75 (2): 152–8. doi:10.1016/j.antiviral.2007.02.002. PMID 17395278.