Ebselen

From Wikipedia, the free encyclopedia

Ebselen
Skeletal formula of ebselen
Ball-and-stick model of the ebselen molecule
IUPAC name 2-Phenyl-1,2-benzoselenazol-3-one
Identifiers
CAS number [60940-34-3]
PubChem 3194
SMILES C1=CC=C(C=C1)N2C(=O)C3=CC=CC=C3[Se]2
Properties
Molecular formula C13H9NOSe
Molar mass 274.17666
Except where noted otherwise, data are given for
materials in their standard state
(at 25 °C, 100 kPa)
Infobox disclaimer and references

Ebselen or 2-phenyl-1, 2-benzisoselenazol-3(2H)-one (also called PZ 51 or DR3305), is a mimic of glutathione peroxidase and can also react with peroxynitrite.[1] It is being investigated as a possible treatment for reperfusion injury and stroke.[2][3]

[edit] References

  1. ^ Schewe T (1995). "Molecular actions of ebselen--an antiinflammatory antioxidant". Gen Pharmacol 26 (6): 1153–69. PMID 7590103. 
  2. ^ Parnham M, Sies H (2000). "Ebselen: prospective therapy for cerebral ischaemia". Expert Opin Investig Drugs 9 (3): 607–19. doi:10.1517/13543784.9.3.607. PMID 11060699. 
  3. ^ Yamaguchi T, Sano K, Takakura K, Saito I, Shinohara Y, Asano T, Yasuhara H (1998). "Ebselen in acute ischemic stroke: a placebo-controlled, double-blind clinical trial. Ebselen Study Group". Stroke 29 (1): 12–7. PMID 9445321. 


 This biochemistry article is a stub. You can help Wikipedia by expanding it.