EBI3

From Wikipedia, the free encyclopedia

Epstein-Barr virus induced gene 3

Identifiers

External IDs

OMIM: 605816 MGI: 1354171 HomoloGene: 4207

Gene ontology
Molecular Function:	• hematopoietin/interferon-class (D200-domain) cytokine receptor activity • protein binding • interleukin binding • interleukin-27 receptor binding
Cellular Component:	• extracellular space • plasma membrane
Biological Process:	• humoral immune response • T-helper 1 type immune response • positive regulation of interferon-gamma biosynthetic process • positive regulation of alpha-beta T cell proliferation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_005755 (mRNA)
NP_005746 (protein)

NM_015766 (mRNA)
NP_056581 (protein)

Location

Chr 19: 4.18 - 4.19 Mb

Chr 17: 55.55 - 55.55 Mb

Pubmed search

[1]

[2]

Epstein-Barr virus induced gene 3, also known as EBI3, is a human gene.^[1]

This gene was identified by the induction of its expression in B lymphocytes by Epstein-Barr virus infection. The protein encoded by this gene is a secreted glycoprotein, which is a member of the hematopoietin receptor family related to the p40 subunit of interleukin 12 (IL-12). It might play a role in regulating cell-mediated immune responses.^[1]

[edit] References

^ ^a ^b Entrez Gene: EBI3 Epstein-Barr virus induced gene 3.

[edit] Further reading

Small RD (1976). "Letter: Statistical analysis of respiratory sensitivity to CO2.". N. Engl. J. Med. 295 (7): 397. PMID 934235.
Devergne O, Hummel M, Koeppen H, et al. (1996). "A novel interleukin-12 p40-related protein induced by latent Epstein-Barr virus infection in B lymphocytes.". J. Virol. 70 (2): 1143-53. PMID 8551575.
Devergne O, Birkenbach M, Kieff E (1997). "Epstein-Barr virus-induced gene 3 and the p35 subunit of interleukin 12 form a novel heterodimeric hematopoietin.". Proc. Natl. Acad. Sci. U.S.A. 94 (22): 12041-6. PMID 9342359.
Pflanz S, Timans JC, Cheung J, et al. (2002). "IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4(+) T cells.". Immunity 16 (6): 779-90. PMID 12121660.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Larousserie F, Pflanz S, Coulomb-L'Herminé A, et al. (2004). "Expression of IL-27 in human Th1-associated granulomatous diseases.". J. Pathol. 202 (2): 164-71. doi:10.1002/path.1508. PMID 14743498.
Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19.". Nature 428 (6982): 529-35. doi:10.1038/nature02399. PMID 15057824.
Gehlert T, Devergne O, Niedobitek G (2004). "Epstein-Barr virus (EBV) infection and expression of the interleukin-12 family member EBV-induced gene 3 (EBI3) in chronic inflammatory bowel disease.". J. Med. Virol. 73 (3): 432-8. doi:10.1002/jmv.20109. PMID 15170639.
Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway.". Genome Res. 14 (7): 1324-32. doi:10.1101/gr.2334104. PMID 15231748.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514.