EBAG9

From Wikipedia, the free encyclopedia

Estrogen receptor binding site associated, antigen, 9

Identifiers

EBAG9; EB9; PDAF; RCAS1

External IDs

OMIM: 605772 MGI: 1859920 HomoloGene: 3107

Gene ontology
Molecular Function:	• apoptotic protease activator activity
Cellular Component:	• soluble fraction • membrane • integral to membrane
Biological Process:	• regulation of cell growth • apoptosis

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_004215 (mRNA)
NP_004206 (protein)

NM_019480 (mRNA)
NP_062353 (protein)

Location

Chr 8: 110.62 - 110.65 Mb

Chr 15: 44.45 - 44.47 Mb

Pubmed search

[1]

[2]

Estrogen receptor binding site associated, antigen, 9, also known as EBAG9, is a human gene.

This gene was identified as an estrogen-responsive gene. Regulation of transcription by estrogen is mediated by estrogen receptor which binds to the estrogen-responsive element (ERE) found in the 5'-flanking region of this gene. The encoded protein is a tumor-associated antigen that is expressed at high frequency in a variety of cancers. Two transcript variants differing in the 5' UTR, but encoding the same protein, have been identified for this gene.^[1]

[edit] References

^ Entrez Gene: EBAG9 estrogen receptor binding site associated, antigen, 9.

[edit] Further reading

Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. PMID 8889548.
Watanabe T, Inoue S, Hiroi H, et al. (1998). "Isolation of estrogen-responsive genes with a CpG island library.". Mol. Cell. Biol. 18 (1): 442–9. PMID 9418891.
Nakashima M, Sonoda K, Watanabe T (1999). "Inhibition of cell growth and induction of apoptotic cell death by the human tumor-associated antigen RCAS1.". Nat. Med. 5 (8): 938–42. doi:10.1038/11383. PMID 10426319.
Ikeda K, Sato M, Tsutsumi O, et al. (2000). "Promoter analysis and chromosomal mapping of human EBAG9 gene.". Biochem. Biophys. Res. Commun. 273 (2): 654–60. doi:10.1006/bbrc.2000.2920. PMID 10873660.
Ohshima K, Nakashima M, Sonoda K, et al. (2001). "Expression of RCAS1 and FasL in human trophoblasts and uterine glands during pregnancy: the possible role in immune privilege.". Clin. Exp. Immunol. 123 (3): 481–6. PMID 11298137.
Matsushima T, Nakashima M, Oshima K, et al. (2001). "Receptor binding cancer antigen expressed on SiSo cells, a novel regulator of apoptosis of erythroid progenitor cells.". Blood 98 (2): 313–21. PMID 11435298.
Tsuneizumi M, Emi M, Nagai H, et al. (2002). "Overrepresentation of the EBAG9 gene at 8q23 associated with early-stage breast cancers.". Clin. Cancer Res. 7 (11): 3526–32. PMID 11705872.
Umeoka K, Sanno N, Oyama K, et al. (2002). "Immunohistochemical analysis of RCAS1 in human pituitary adenomas.". Mod. Pathol. 14 (12): 1232–6. doi:10.1038/modpathol.3880467. PMID 11743045.
Hiraoka K, Hida Y, Miyamoto M, et al. (2002). "High expression of tumor-associated antigen RCAS1 in pancreatic ductal adenocarcinoma is an unfavorable prognostic marker.". Int. J. Cancer 99 (3): 418–23. doi:10.1002/ijc.10381. PMID 11992411.
Rousseau J, Têtu B, Caron D, et al. (2002). "RCAS1 is associated with ductal breast cancer progression.". Biochem. Biophys. Res. Commun. 293 (5): 1544–9. doi:10.1016/S0006-291X(02)00401-1. PMID 12054692.
Oizumi S, Yamazaki K, Nakashima M, et al. (2002). "RCAS1 expression: a potential prognostic marker for adenocarcinomas of the lung.". Oncology 62 (4): 333–9. PMID 12138241.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Engelsberg A, Hermosilla R, Karsten U, et al. (2003). "The Golgi protein RCAS1 controls cell surface expression of tumor-associated O-linked glycan antigens.". J. Biol. Chem. 278 (25): 22998–3007. doi:10.1074/jbc.M301361200. PMID 12672804.
Abe Y, Ohshima K, Nakashima M, et al. (2003). "Expression of apoptosis-associated protein RCAS1 in macrophages of histiocytic necrotizing lymphadenitis.". Int. J. Hematol. 77 (4): 359–63. PMID 12774924.
Takahashi S, Urano T, Tsuchiya F, et al. (2003). "EBAG9/RCAS1 expression and its prognostic significance in prostatic cancer.". Int. J. Cancer 106 (3): 310–5. doi:10.1002/ijc.11205. PMID 12845666.
Sonoda K, Miyamoto S, Hirakawa T, et al. (2003). "Association between RCAS1 expression and clinical outcome in uterine endometrial cancer.". Br. J. Cancer 89 (3): 546–51. doi:10.1038/sj.bjc.6601126. PMID 12888828.
Leelawat K, Watanabe T, Nakajima M, et al. (2003). "Upregulation of tumour associated antigen RCAS1 is implicated in high stages of colorectal cancer.". J. Clin. Pathol. 56 (10): 764–8. PMID 14514780.
Ikeguchi M, Ohoro S, Maeda Y, et al. (2004). "Protein and gene expression of tumor-associated antigen RCAS1 in esophageal squamous cell carcinoma.". Oncol. Rep. 10 (6): 1891–4. PMID 14534714.
Ikeguchi M, Hirooka Y, Kaibara N (2004). "Gene and protein expression of RCAS1 in hepatocellular carcinoma.". Anticancer Res. 23 (6D): 4967–71. PMID 14981953.
Brill LM, Salomon AR, Ficarro SB, et al. (2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.". Anal. Chem. 76 (10): 2763–72. doi:10.1021/ac035352d. PMID 15144186.