EAPP
From Wikipedia, the free encyclopedia
Chromosome 14 open reading frame 11
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Identifiers | ||||||||
Symbol(s) | C14orf11; BM036; EAPP; FLJ20578; MGC4957 | |||||||
External IDs | OMIM: 609486 MGI: 1913516 HomoloGene: 10206 | |||||||
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RNA expression pattern | ||||||||
Orthologs | ||||||||
Human | Mouse | |||||||
Entrez | 55837 | 66266 | ||||||
Ensembl | ENSG00000129518 | ENSMUSG00000054302 | ||||||
Uniprot | Q56P03 | Q3UM97 | ||||||
Refseq | NM_018453 (mRNA) NP_060923 (protein) |
NM_025456 (mRNA) NP_079732 (protein) |
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Location | Chr 14: 34.05 - 34.08 Mb | Chr 12: 55.6 - 55.62 Mb | ||||||
Pubmed search | [1] | [2] |
Chromosome 14 open reading frame 11, also known as C14orf11, is a human gene.[1]
This gene encodes a phosphoprotein that interacts with several members of the E2F family of proteins. The protein localizes to the nucleus, and is present throughout the cell cycle except during mitosis. It functions to modulate E2F-regulated transcription and stimulate proliferation.[1]
[edit] References
[edit] Further reading
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171-4. PMID 8125298.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149-56. PMID 9373149.
- Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.". Genome Res. 10 (10): 1546-60. PMID 11042152.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi: . PMID 12477932.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi: . PMID 14702039.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi: . PMID 15489334.
- Novy M, Pohn R, Andorfer P, et al. (2005). "EAPP, a novel E2F binding protein that modulates E2F-dependent transcription.". Mol. Biol. Cell 16 (5): 2181-90. doi: . PMID 15716352.
- Kamnasaran D, Chen CP, Devriendt K, et al. (2005). "Defining a holoprosencephaly locus on human chromosome 14q13 and characterization of potential candidate genes.". Genomics 85 (5): 608-21. doi: . PMID 15820313.
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi: . PMID 16189514.
- Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.". Cell 125 (4): 801-14. doi: . PMID 16713569.
- Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635-48. doi: . PMID 17081983.