EAF2

From Wikipedia, the free encyclopedia

ELL associated factor 2

Identifiers

EAF2; U19; BM040; TRAITS

External IDs

Gene ontology
Molecular Function:	• protein binding • transcription activator activity
Cellular Component:	• nucleus • nucleoplasm
Biological Process:	• transcription • regulation of transcription, DNA-dependent • apoptosis • positive regulation of transcription

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

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Refseq

NM_018456 (mRNA)
NP_060926 (protein)

n/a (mRNA)
n/a (protein)

Location

Chr 3: 123.04 - 123.09 Mb

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Pubmed search

[1]

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ELL associated factor 2, also known as EAF2, is a human gene.^[1]

[edit] References

^ Entrez Gene: EAF2 ELL associated factor 2.

[edit] Further reading

Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.". Genome Res. 10 (10): 1546-60. PMID 11042152.
Simone F, Luo RT, Polak PE, et al. (2003). "ELL-associated factor 2 (EAF2), a functional homolog of EAF1 with alternative ELL binding properties.". Blood 101 (6): 2355-62. doi:10.1182/blood-2002-06-1664. PMID 12446457.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Saso K, Ito T, Natori S, Sekimizu K (2004). "Identification of a novel tissue-specific transcriptional activator FESTA as a protein that interacts with the transcription elongation factor S-II.". J. Biochem. 133 (4): 493-500. PMID 12761297.
Xiao W, Zhang Q, Jiang F, et al. (2003). "Suppression of prostate tumor growth by U19, a novel testosterone-regulated apoptosis inducer.". Cancer Res. 63 (15): 4698-704. PMID 12907652.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Kong SE, Banks CA, Shilatifard A, et al. (2005). "ELL-associated factors 1 and 2 are positive regulators of RNA polymerase II elongation factor ELL.". Proc. Natl. Acad. Sci. U.S.A. 102 (29): 10094-8. doi:10.1073/pnas.0503017102. PMID 16006523.
Xiao W, Jiang F, Wang Z (2006). "ELL binding regulates U19/Eaf2 intracellular localization, stability, and transactivation.". Prostate 66 (1): 1-12. doi:10.1002/pros.20309. PMID 16114057.
Jiang F, Ai J, Xiao W, Wang Z (2007). "FB1, an E2A fusion partner in childhood leukemia, interacts with U19/EAF2 and inhibits its transcriptional activity.". Cancer Lett. 253 (2): 265-72. doi:10.1016/j.canlet.2007.02.003. PMID 17395368.