DYRK1B

From Wikipedia, the free encyclopedia

Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B

Identifiers

External IDs

OMIM: 604556 MGI: 1330302 HomoloGene: 31253

Gene ontology
Molecular Function:	• nucleotide binding • transcription coactivator activity • protein serine/threonine kinase activity • protein-tyrosine kinase activity • protein binding • ATP binding • transferase activity
Cellular Component:	• nucleus
Biological Process:	• protein amino acid phosphorylation • myoblast fusion • positive regulation of transcription, DNA-dependent

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

Refseq

NM_004714 (mRNA)
NP_004705 (protein)

XM_992180 (mRNA)
XP_997274 (protein)

Location

Chr 19: 45.01 - 45.02 Mb

Chr 7: 27.89 - 27.9 Mb

Pubmed search

[1]

[2]

Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B, also known as DYRK1B, is a human gene.^[1]

DYRK1B is a member of the DYRK family of protein kinases. DYRK1B contains a bipartite nuclear localization signal and is found mainly in muscle and testis. The protein is proposed to be involved in the regulation of nuclear functions. Three isoforms of DYRK1B have been identified differing in the presence of two alternatively spliced exons within the catalytic domain.^[1]

[edit] References

^ ^a ^b Entrez Gene: DYRK1B dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B.

[edit] Further reading

Mercer SE, Friedman E (2006). "Mirk/Dyrk1B: a multifunctional dual-specificity kinase involved in growth arrest, differentiation, and cell survival.". Cell Biochem. Biophys. 45 (3): 303–15. PMID 16845176.
Leder S, Weber Y, Altafaj X, et al. (1999). "Cloning and characterization of DYRK1B, a novel member of the DYRK family of protein kinases.". Biochem. Biophys. Res. Commun. 254 (2): 474–9. doi:10.1006/bbrc.1998.9967. PMID 9918863.
Lee K, Deng X, Friedman E (2000). "Mirk protein kinase is a mitogen-activated protein kinase substrate that mediates survival of colon cancer cells.". Cancer Res. 60 (13): 3631–7. PMID 10910078.
Lim S, Jin K, Friedman E (2002). "Mirk protein kinase is activated by MKK3 and functions as a transcriptional activator of HNF1alpha.". J. Biol. Chem. 277 (28): 25040–6. doi:10.1074/jbc.M203257200. PMID 11980910.
Lim S, Zou Y, Friedman E (2003). "The transcriptional activator Mirk/Dyrk1B is sequestered by p38alpha/beta MAP kinase.". J. Biol. Chem. 277 (51): 49438–45. doi:10.1074/jbc.M206840200. PMID 12384504.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Zou Y, Lim S, Lee K, et al. (2004). "Serine/threonine kinase Mirk/Dyrk1B is an inhibitor of epithelial cell migration and is negatively regulated by the Met adaptor Ran-binding protein M.". J. Biol. Chem. 278 (49): 49573–81. doi:10.1074/jbc.M307556200. PMID 14500717.
Skurat AV, Dietrich AD (2004). "Phosphorylation of Ser640 in muscle glycogen synthase by DYRK family protein kinases.". J. Biol. Chem. 279 (4): 2490–8. doi:10.1074/jbc.M301769200. PMID 14593110.
Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19.". Nature 428 (6982): 529–35. doi:10.1038/nature02399. PMID 15057824.
Brill LM, Salomon AR, Ficarro SB, et al. (2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.". Anal. Chem. 76 (10): 2763–72. doi:10.1021/ac035352d. PMID 15144186.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Deng X, Ewton DZ, Mercer SE, Friedman E (2005). "Mirk/dyrk1B decreases the nuclear accumulation of class II histone deacetylases during skeletal muscle differentiation.". J. Biol. Chem. 280 (6): 4894–905. doi:10.1074/jbc.M411894200. PMID 15546868.
Mercer SE, Ewton DZ, Deng X, et al. (2005). "Mirk/Dyrk1B mediates survival during the differentiation of C2C12 myoblasts.". J. Biol. Chem. 280 (27): 25788–801. doi:10.1074/jbc.M413594200. PMID 15851482.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Deng X, Ewton DZ, Li S, et al. (2006). "The kinase Mirk/Dyrk1B mediates cell survival in pancreatic ductal adenocarcinoma.". Cancer Res. 66 (8): 4149–58. doi:10.1158/0008-5472.CAN-05-3089. PMID 16618736.
Takahashi-Yanaga F, Mori J, Matsuzaki E, et al. (2007). "Involvement of GSK-3beta and DYRK1B in differentiation-inducing factor-3-induced phosphorylation of cyclin D1 in HeLa cells.". J. Biol. Chem. 281 (50): 38489–97. doi:10.1074/jbc.M605205200. PMID 17046823.