DYNLT1

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Dynein, light chain, Tctex-type 1
Identifiers
Symbol(s) DYNLT1; CW-1; MGC111571; TCTEL1; tctex-1
External IDs OMIM: 601554 MGI: 98643 HomoloGene: 4754
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 6993 21648
Ensembl ENSG00000146425 n/a
Uniprot P63172 n/a
Refseq NM_006519 (mRNA)
NP_006510 (protein)		 XM_001006801 (mRNA)
XP_001006801 (protein)
Location Chr 6: 158.98 - 158.99 Mb n/a
Pubmed search [1] [2]

Dynein, light chain, Tctex-type 1, also known as DYNLT1, is a human gene.[1]

Cytoplasmic dynein is the major motor protein complex responsible for minus-end, microtubule-based motile processes. Each dynein complex consists of 2 heavy chains that have ATPase and motor activities, plus a group of accessory polypeptides. TCTEX1 is a dynein light chain involved in cargo binding (Chuang et al., 2005).[supplied by OMIM][1]

[edit] References

  1. ^ a b Entrez Gene: DYNLT1 dynein, light chain, Tctex-type 1.

[edit] Further reading

  • Tete R, de Montgolfier R, Piante M (1971). "[Leiomyoma and leiomyosarcoma of the small intestine. Value of selective angiography]". Journal de médecine de Lyon 52 (192): 1523-6 passim. PMID 5503857. 
  • Watanabe TK, Fujiwara T, Shimizu F, et al. (1996). "Cloning, expression, and mapping of TCTEL1, a putative human homologue of murine Tcte1, to 6q.". Cytogenet. Cell Genet. 73 (1-2): 153-6. PMID 8646886. 
  • King SM, Dillman JF, Benashski SE, et al. (1997). "The mouse t-complex-encoded protein Tctex-1 is a light chain of brain cytoplasmic dynein.". J. Biol. Chem. 271 (50): 32281-7. PMID 8943288. 
  • Nagano F, Orita S, Sasaki T, et al. (1998). "Interaction of Doc2 with tctex-1, a light chain of cytoplasmic dynein. Implication in dynein-dependent vesicle transport.". J. Biol. Chem. 273 (46): 30065-8. PMID 9804756. 
  • Strovel ET, Wu D, Sussman DJ (2000). "Protein phosphatase 2Calpha dephosphorylates axin and activates LEF-1-dependent transcription.". J. Biol. Chem. 275 (4): 2399-403. PMID 10644691. 
  • Mueller S, Cao X, Welker R, Wimmer E (2002). "Interaction of the poliovirus receptor CD155 with the dynein light chain Tctex-1 and its implication for poliovirus pathogenesis.". J. Biol. Chem. 277 (10): 7897-904. doi:10.1074/jbc.M111937200. PMID 11751937. 
  • Schwarzer C, Barnikol-Watanabe S, Thinnes FP, Hilschmann N (2002). "Voltage-dependent anion-selective channel (VDAC) interacts with the dynein light chain Tctex1 and the heat-shock protein PBP74.". Int. J. Biochem. Cell Biol. 34 (9): 1059-70. PMID 12009301. 
  • Nadano D, Nakayama J, Matsuzawa S, et al. (2002). "Human tastin, a proline-rich cytoplasmic protein, associates with the microtubular cytoskeleton.". Biochem. J. 364 (Pt 3): 669-77. doi:10.1042/BJ20011836. PMID 12049630. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Machado RD, Rudarakanchana N, Atkinson C, et al. (2004). "Functional interaction between BMPR-II and Tctex-1, a light chain of Dynein, is isoform-specific and disrupted by mutations underlying primary pulmonary hypertension.". Hum. Mol. Genet. 12 (24): 3277-86. doi:10.1093/hmg/ddg365. PMID 14583445. 
  • Douglas MW, Diefenbach RJ, Homa FL, et al. (2004). "Herpes simplex virus type 1 capsid protein VP26 interacts with dynein light chains RP3 and Tctex1 and plays a role in retrograde cellular transport.". J. Biol. Chem. 279 (27): 28522-30. doi:10.1074/jbc.M311671200. PMID 15117959. 
  • Ohka S, Matsuda N, Tohyama K, et al. (2004). "Receptor (CD155)-dependent endocytosis of poliovirus and retrograde axonal transport of the endosome.". J. Virol. 78 (13): 7186-98. doi:10.1128/JVI.78.13.7186-7198.2004. PMID 15194795. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334. 
  • de Wit NJ, Verschuure P, Kappé G, et al. (2005). "Testis-specific human small heat shock protein HSPB9 is a cancer/testis antigen, and potentially interacts with the dynein subunit TCTEL1.". Eur. J. Cell Biol. 83 (7): 337-45. PMID 15503857. 
  • Chuang JZ, Yeh TY, Bollati F, et al. (2005). "The dynein light chain Tctex-1 has a dynein-independent role in actin remodeling during neurite outgrowth.". Dev. Cell 9 (1): 75-86. doi:10.1016/j.devcel.2005.04.003. PMID 15992542. 
  • Pfister KK, Fisher EM, Gibbons IR, et al. (2006). "Cytoplasmic dynein nomenclature.". J. Cell Biol. 171 (3): 411-3. doi:10.1083/jcb.200508078. PMID 16260502. 
  • Yeh TY, Peretti D, Chuang JZ, et al. (2007). "Regulatory dissociation of Tctex-1 light chain from dynein complex is essential for the apical delivery of rhodopsin.". Traffic 7 (11): 1495-502. doi:10.1111/j.1600-0854.2006.00482.x. PMID 16956385. 
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