DYNLRB1

From Wikipedia, the free encyclopedia

Dynein, light chain, roadblock-type 1

PDB rendering based on 1y4o.

Available structures: 1y4o, 1z09, 2b95

Identifiers

Symbol(s)

DYNLRB1; BITH; BLP; DNCL2A; DNLC2A

External IDs

OMIM: 607167 MGI: 1914318 HomoloGene: 69161

Gene ontology
Molecular Function:	• microtubule motor activity • protein binding
Cellular Component:	• cytoplasm • cytoplasmic dynein complex • microtubule
Biological Process:	• microtubule-based movement • visual behavior • retrograde axon cargo transport

Orthologs

Human

Mouse

Refseq

NM_014183 (mRNA)
NP_054902 (protein)

XM_976951 (mRNA)
XP_982045 (protein)

Location

Chr 20: 32.57 - 32.59 Mb

Chr 2: 154.93 - 154.94 Mb

Pubmed search

[1]

[2]

Dynein, light chain, roadblock-type 1, also known as DYNLRB1, is a human gene.^[1]

This gene is a member of the roadblock dynein light chain family and encodes a cytoplasmic protein that is capable of binding intermediate chain proteins. Upregulation of this gene has been associated with hepatocellular carcinomas, suggesting that this gene may be involved in tumor progression.^[1]

[edit] References

^ ^a ^b Entrez Gene: DYNLRB1 dynein, light chain, roadblock-type 1.

[edit] Further reading

Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.". Genome Res. 10 (10): 1546-60. PMID 11042152.
Jiang J, Yu L, Huang X, et al. (2002). "Identification of two novel human dynein light chain genes, DNLC2A and DNLC2B, and their expression changes in hepatocellular carcinoma tissues from 68 Chinese patients.". Gene 281 (1-2): 103-13. PMID 11750132.
Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20.". Nature 414 (6866): 865-71. doi:10.1038/414865a. PMID 11780052.
Susalka SJ, Nikulina K, Salata MW, et al. (2002). "The roadblock light chain binds a novel region of the cytoplasmic Dynein intermediate chain.". J. Biol. Chem. 277 (36): 32939-46. doi:10.1074/jbc.M205510200. PMID 12077152.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Huang YS, Carson JH, Barbarese E, Richter JD (2003). "Facilitation of dendritic mRNA transport by CPEB.". Genes Dev. 17 (5): 638-53. doi:10.1101/gad.1053003. PMID 12629046.
Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.". Nat. Biotechnol. 21 (5): 566-9. doi:10.1038/nbt810. PMID 12665801.
Saito Y, Doi K, Yamagishi N, et al. (2004). "Screening of Hsp105alpha-binding proteins using yeast and bacterial two-hybrid systems.". Biochem. Biophys. Res. Commun. 314 (2): 396-402. PMID 14733918.
Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation.". Genome Res. 14 (7): 1315-23. doi:10.1101/gr.2122004. PMID 15231747.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514.
Pfister KK, Fisher EM, Gibbons IR, et al. (2006). "Cytoplasmic dynein nomenclature.". J. Cell Biol. 171 (3): 411-3. doi:10.1083/jcb.200508078. PMID 16260502.
Campbell IG, Phillips WA, Choong DY (2006). "Genetic and epigenetic analysis of the putative tumor suppressor km23 in primary ovarian, breast, and colorectal cancers.". Clin. Cancer Res. 12 (12): 3713-5. doi:10.1158/1078-0432.CCR-06-0800. PMID 16778097.
Pérez-González A, Rodriguez A, Huarte M, et al. (2007). "hCLE/CGI-99, a human protein that interacts with the influenza virus polymerase, is a mRNA transcription modulator.". J. Mol. Biol. 362 (5): 887-900. doi:10.1016/j.jmb.2006.07.085. PMID 16950395.
Liu JF, Wang ZX, Wang XQ, et al. (2006). "Crystal structure of human dynein light chain Dnlc2A: structural insights into the interaction with IC74.". Biochem. Biophys. Res. Commun. 349 (3): 1125-9. doi:10.1016/j.bbrc.2006.08.161. PMID 16970917.
Kang HC, Kim IJ, Kim K, et al. (2007). "km23, a transforming growth factor-beta signaling component, is infrequently mutated in human colorectal and gastric cancers.". Cancer Genet. Cytogenet. 175 (2): 173-4. doi:10.1016/j.cancergencyto.2007.02.004. PMID 17556076.