DYNC2H1

From Wikipedia, the free encyclopedia

Dynein, cytoplasmic 2, heavy chain 1

Identifiers

DYNC2H1; DHC1b; DHC2; DNCH2; DYH1B; FLJ11756; hdhc11

External IDs

OMIM: 603297 MGI: 107736 HomoloGene: 14468

Gene ontology
Molecular Function:	• nucleotide binding • motor activity • microtubule motor activity • ATP binding • hydrolase activity • ATPase activity • ATPase activity, coupled • ATPase activity, uncoupled
Cellular Component:	• intracellular • Golgi apparatus • dynein complex
Biological Process:	• microtubule-based movement • Golgi organization and biogenesis

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

Refseq

XM_370652 (mRNA)
XP_370652 (protein)

XM_001005686 (mRNA)
XP_001005686 (protein)

Location

Chr 11: 102.49 - 102.86 Mb

n/a

Pubmed search

[1]

[2]

Dynein, cytoplasmic 2, heavy chain 1, also known as DYNC2H1, is a human gene.^[1]

[edit] References

^ Entrez Gene: DYNC2H1 dynein, cytoplasmic 2, heavy chain 1.

[edit] Further reading

Gibbons BH, Asai DJ, Tang WJ, et al. (1994). "Phylogeny and expression of axonemal and cytoplasmic dynein genes in sea urchins.". Mol. Biol. Cell 5 (1): 57-70. PMID 8186465.
Vaisberg EA, Grissom PM, McIntosh JR (1996). "Mammalian cells express three distinct dynein heavy chains that are localized to different cytoplasmic organelles.". J. Cell Biol. 133 (4): 831-42. PMID 8666668.
Criswell PS, Ostrowski LE, Asai DJ (1997). "A novel cytoplasmic dynein heavy chain: expression of DHC1b in mammalian ciliated epithelial cells.". J. Cell. Sci. 109 ( Pt 7): 1891-8. PMID 8832411.
Kastury K, Taylor WE, Gutierrez M, et al. (1997). "Chromosomal mapping of two members of the human dynein gene family to chromosome regions 7p15 and 11q13 near the deafness loci DFNA 5 and DFNA 11.". Genomics 44 (3): 362-4. doi:10.1006/geno.1997.4903. PMID 9325061.
Neesen J, Koehler MR, Kirschner R, et al. (1997). "Identification of dynein heavy chain genes expressed in human and mouse testis: chromosomal localization of an axonemal dynein gene.". Gene 200 (1-2): 193-202. PMID 9373155.
Koehler MR, Schmid M, Neesen J (1998). "Chromosomal localization of the human cytoplasmic dynein heavy chain gene DNCH2 to 11q21-->q22.1.". Cytogenet. Cell Genet. 82 (1-2): 123-5. PMID 9763680.
Grissom PM, Vaisberg EA, McIntosh JR (2002). "Identification of a novel light intermediate chain (D2LIC) for mammalian cytoplasmic dynein 2.". Mol. Biol. Cell 13 (3): 817-29. doi:10.1091/mbc.01-08-0402. PMID 11907264.
Ohara O, Nagase T, Mitsui G, et al. (2003). "Characterization of size-fractionated cDNA libraries generated by the in vitro recombination-assisted method.". DNA Res. 9 (2): 47-57. PMID 12056414.
Mikami A, Tynan SH, Hama T, et al. (2003). "Molecular structure of cytoplasmic dynein 2 and its distribution in neuronal and ciliated cells.". J. Cell. Sci. 115 (Pt 24): 4801-8. PMID 12432068.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Yokota T, Kouno J, Adachi K, et al. (2006). "Identification of histological markers for malignant glioma by genome-wide expression analysis: dynein, alpha-PIX and sorcin.". Acta Neuropathol. 111 (1): 29-38. doi:10.1007/s00401-005-1085-6. PMID 16320026.