DYNC1I2

From Wikipedia, the free encyclopedia

Dynein, cytoplasmic 1, intermediate chain 2

PDB rendering based on 2pg1.

Available structures: 2pg1

Identifiers

Symbol(s)

DYNC1I2; DNCI2; FLJ21089; FLJ90842; IC2; MGC104199; MGC111094; MGC9324

External IDs

OMIM: 603331 MGI: 107750 HomoloGene: 37921

Gene ontology
Molecular Function:	• microtubule motor activity
Cellular Component:	• cytoplasm • microtubule • dynein complex
Biological Process:	• microtubule-based movement

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001378 (mRNA)
NP_001369 (protein)

NM_010064 (mRNA)
NP_034194 (protein)

Location

Chr 2: 172.25 - 172.31 Mb

Chr 2: 71.01 - 71.06 Mb

Pubmed search

[1]

[2]

Dynein, cytoplasmic 1, intermediate chain 2, also known as DYNC1I2, is a human gene.^[1]

[edit] References

^ Entrez Gene: DYNC1I2 dynein, cytoplasmic 1, intermediate chain 2.

[edit] Further reading

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171-4. PMID 8125298.
Vaughan KT, Vallee RB (1996). "Cytoplasmic dynein binds dynactin through a direct interaction between the intermediate chains and p150Glued.". J. Cell Biol. 131 (6 Pt 1): 1507-16. PMID 8522607.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149-56. PMID 9373149.
Crackower MA, Sinasac DS, Xia J, et al. (1999). "Cloning and characterization of two cytoplasmic dynein intermediate chain genes in mouse and human.". Genomics 55 (3): 257-67. doi:10.1006/geno.1998.5665. PMID 10049579.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788-95. PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422-35. doi:10.1101/gr.154701. PMID 11230166.
Davies TH, Ning YM, Sánchez ER (2002). "A new first step in activation of steroid receptors: hormone-induced switching of FKBP51 and FKBP52 immunophilins.". J. Biol. Chem. 277 (7): 4597-600. doi:10.1074/jbc.C100531200. PMID 11751894.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Fortna A, Kim Y, MacLaren E, et al. (2006). "Lineage-specific gene duplication and loss in human and great ape evolution.". PLoS Biol. 2 (7): E207. doi:10.1371/journal.pbio.0020207. PMID 15252450.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130-5. doi:10.1073/pnas.0404720101. PMID 15302935.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline.". Genome Res. 14 (10B): 2136-44. doi:10.1101/gr.2576704. PMID 15489336.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514.
Pfister KK, Fisher EM, Gibbons IR, et al. (2006). "Cytoplasmic dynein nomenclature.". J. Cell Biol. 171 (3): 411-3. doi:10.1083/jcb.200508078. PMID 16260502.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006.". Nucleic Acids Res. 34 (Database issue): D415-8. doi:10.1093/nar/gkj139. PMID 16381901.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.