DYNC1H1

From Wikipedia, the free encyclopedia

Dynein, cytoplasmic 1, heavy chain 1

Identifiers

DYNC1H1; DHC1; DHC1a; DKFZp686P2245; DNCH1; DNCL; DNECL; DYHC; Dnchc1; HL-3; KIAA0325; p22

External IDs

OMIM: 600112 MGI: 103147 HomoloGene: 1053

Gene ontology
Molecular Function:	• nucleotide binding • microtubule motor activity • protein binding • ATP binding • ATPase activity, coupled
Cellular Component:	• cytoplasmic dynein complex • microtubule • dynein complex
Biological Process:	• microtubule-based movement • mitotic spindle organization and biogenesis

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001376 (mRNA)
NP_001367 (protein)

NM_030238 (mRNA)
NP_084514 (protein)

Location

Chr 14: 101.5 - 101.59 Mb

Chr 12: 111.05 - 111.11 Mb

Pubmed search

[1]

[2]

Dynein, cytoplasmic 1, heavy chain 1, also known as DYNC1H1, is a human gene.^[1]

[edit] References

^ Entrez Gene: DYNC1H1 dynein, cytoplasmic 1, heavy chain 1.

[edit] Further reading

Narayan D, Desai T, Banks A, et al. (1995). "Localization of the human cytoplasmic dynein heavy chain (DNECL) to 14qter by fluorescence in situ hybridization.". Genomics 22 (3): 660–1. doi:10.1006/geno.1994.1447. PMID 8001984.
Vaisberg EA, Koonce MP, McIntosh JR (1993). "Cytoplasmic dynein plays a role in mammalian mitotic spindle formation.". J. Cell Biol. 123 (4): 849–58. PMID 8227145.
Vaisberg EA, Grissom PM, McIntosh JR (1996). "Mammalian cells express three distinct dynein heavy chains that are localized to different cytoplasmic organelles.". J. Cell Biol. 133 (4): 831–42. PMID 8666668.
Vaughan KT, Mikami A, Paschal BM, et al. (1997). "Multiple mouse chromosomal loci for dynein-based motility.". Genomics 36 (1): 29–38. doi:10.1006/geno.1996.0422. PMID 8812413.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. PMID 8889548.
Nagase T, Ishikawa K, Nakajima D, et al. (1997). "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.". DNA Res. 4 (2): 141–50. PMID 9205841.
Neesen J, Koehler MR, Kirschner R, et al. (1997). "Identification of dynein heavy chain genes expressed in human and mouse testis: chromosomal localization of an axonemal dynein gene.". Gene 200 (1-2): 193–202. PMID 9373155.
Byers HR, Yaar M, Eller MS, et al. (2000). "Role of cytoplasmic dynein in melanosome transport in human melanocytes.". J. Invest. Dermatol. 114 (5): 990–7. doi:10.1046/j.1523-1747.2000.00957.x. PMID 10771482.
Habermann A, Schroer TA, Griffiths G, Burkhardt JK (2001). "Immunolocalization of cytoplasmic dynein and dynactin subunits in cultured macrophages: enrichment on early endocytic organelles.". J. Cell. Sci. 114 (Pt 1): 229–240. PMID 11112706.
Sasaki S, Shionoya A, Ishida M, et al. (2001). "A LIS1/NUDEL/cytoplasmic dynein heavy chain complex in the developing and adult nervous system.". Neuron 28 (3): 681–96. PMID 11163259.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Payne C, Rawe V, Ramalho-Santos J, et al. (2004). "Preferentially localized dynein and perinuclear dynactin associate with nuclear pore complex proteins to mediate genomic union during mammalian fertilization.". J. Cell. Sci. 116 (Pt 23): 4727–38. doi:10.1242/jcs.00784. PMID 14600259.
Byers HR, Maheshwary S, Amodeo DM, Dykstra SG (2003). "Role of cytoplasmic dynein in perinuclear aggregation of phagocytosed melanosomes and supranuclear melanin cap formation in human keratinocytes.". J. Invest. Dermatol. 121 (4): 813–20. doi:10.1046/j.1523-1747.2003.12481.x. PMID 14632200.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Navarro-Lérida I, Martínez Moreno M, Roncal F, et al. (2004). "Proteomic identification of brain proteins that interact with dynein light chain LC8.". Proteomics 4 (2): 339–46. doi:10.1002/pmic.200300528. PMID 14760703.
Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway.". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMID 15231748.
Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization.". Curr. Biol. 14 (16): 1436–50. doi:10.1016/j.cub.2004.07.051. PMID 15324660.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics.". Nature 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413.
Pfister KK, Fisher EM, Gibbons IR, et al. (2006). "Cytoplasmic dynein nomenclature.". J. Cell Biol. 171 (3): 411–3. doi:10.1083/jcb.200508078. PMID 16260502.