DUSP7

From Wikipedia, the free encyclopedia

Dual specificity phosphatase 7

Identifiers

DUSP7; MKP-X; MKPX; PYST2

External IDs

OMIM: 602749 MGI: 2387100 HomoloGene: 1468

Gene ontology
Molecular Function:	• protein serine/threonine phosphatase activity • protein tyrosine phosphatase activity • hydrolase activity • MAP kinase tyrosine/serine/threonine phosphatase activity
Biological Process:	• protein amino acid dephosphorylation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

n/a

Refseq

NM_001947 (mRNA)
NP_001938 (protein)

XM_974684 (mRNA)
XP_979778 (protein)

Location

Chr 3: 52.06 - 52.07 Mb

n/a

Pubmed search

[1]

[2]

Dual specificity phosphatase 7, also known as DUSP7, is a human gene.^[1]

[edit] References

^ Entrez Gene: DUSP7 dual specificity phosphatase 7.

[edit] Further reading

Muda M, Boschert U, Dickinson R, et al. (1996). "MKP-3, a novel cytosolic protein-tyrosine phosphatase that exemplifies a new class of mitogen-activated protein kinase phosphatase.". J. Biol. Chem. 271 (8): 4319–26. PMID 8626780.
Groom LA, Sneddon AA, Alessi DR, et al. (1996). "Differential regulation of the MAP, SAP and RK/p38 kinases by Pyst1, a novel cytosolic dual-specificity phosphatase.". EMBO J. 15 (14): 3621–32. PMID 8670865.
Smith A, Price C, Cullen M, et al. (1997). "Chromosomal localization of three human dual specificity phosphatase genes (DUSP4, DUSP6, and DUSP7).". Genomics 42 (3): 524–7. doi:10.1006/geno.1997.4756. PMID 9205128.
Dowd S, Sneddon AA, Keyse SM (1999). "Isolation of the human genes encoding the pyst1 and Pyst2 phosphatases: characterisation of Pyst2 as a cytosolic dual-specificity MAP kinase phosphatase and its catalytic activation by both MAP and SAP kinases.". J. Cell. Sci. 111 ( Pt 22): 3389–99. PMID 9788880.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Pasquali C, Curchod ML, Wälchli S, et al. (2004). "Identification of protein tyrosine phosphatases with specificity for the ligand-activated growth hormone receptor.". Mol. Endocrinol. 17 (11): 2228–39. doi:10.1210/me.2003-0011. PMID 12907755.
Levy-Nissenbaum O, Sagi-Assif O, Kapon D, et al. (2003). "Dual-specificity phosphatase Pyst2-L is constitutively highly expressed in myeloid leukemia and other malignant cells.". Oncogene 22 (48): 7649–60. doi:10.1038/sj.onc.1206971. PMID 14576828.
Levy-Nissenbaum O, Sagi-Assif O, Witz IP (2004). "Characterization of the dual-specificity phosphatase PYST2 and its transcripts.". Genes Chromosomes Cancer 39 (1): 37–47. doi:10.1002/gcc.10295. PMID 14603440.
Levy-Nissenbaum O, Sagi-Assif O, Raanani P, et al. (2004). "cDNA microarray analysis reveals an overexpression of the dual-specificity MAPK phosphatase PYST2 in acute leukemia.". Meth. Enzymol. 366: 103–13. PMID 14674243.
Orlev LN, Ehud B, Tamar BG, et al. (2004). "Does the dual-specificity MAPK phosphatase Pyst2-L lead a monogamous relationship with the Erk2 protein?". Immunol. Lett. 92 (1-2): 149–56. doi:10.1016/j.imlet.2003.11.024. PMID 15081539.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.