DUSP5

From Wikipedia, the free encyclopedia

Dual specificity phosphatase 5

PDB rendering based on 2g6z.

Available structures: 2g6z

Identifiers

Symbol(s)

DUSP5; DUSP; HVH3

External IDs

OMIM: 603069 MGI: 2685183 HomoloGene: 3256

Gene ontology
Molecular Function:	• protein tyrosine phosphatase activity • hydrolase activity • MAP kinase tyrosine/serine/threonine phosphatase activity
Cellular Component:	• nucleus
Biological Process:	• protein amino acid dephosphorylation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

Refseq

NM_004419 (mRNA)
NP_004410 (protein)

XM_140740 (mRNA)
XP_140740 (protein)

Location

Chr 10: 112.25 - 112.26 Mb

Chr 19: 53.58 - 53.59 Mb

Pubmed search

[1]

[2]

Dual specificity phosphatase 5, also known as DUSP5, is a human gene.^[1]

The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1, is expressed in a variety of tissues with the highest levels in pancreas and brain, and is localized in the nucleus.^[1]

[edit] References

^ ^a ^b Entrez Gene: DUSP5 dual specificity phosphatase 5.

[edit] Further reading

Martell KJ, Kwak S, Hakes DJ, et al. (1995). "Chromosomal localization of four human VH1-like protein-tyrosine phosphatases.". Genomics 22 (2): 462-4. doi:10.1006/geno.1994.1411. PMID 7806236.
Robertson NG, Khetarpal U, Gutiérrez-Espeleta GA, et al. (1995). "Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening.". Genomics 23 (1): 42-50. doi:10.1006/geno.1994.1457. PMID 7829101.
Kwak SP, Dixon JE (1995). "Multiple dual specificity protein tyrosine phosphatases are expressed and regulated differentially in liver cell lines.". J. Biol. Chem. 270 (3): 1156-60. PMID 7836374.
Ishibashi T, Bottaro DP, Michieli P, et al. (1994). "A novel dual specificity phosphatase induced by serum stimulation and heat shock.". J. Biol. Chem. 269 (47): 29897-902. PMID 7961985.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Ueda K, Arakawa H, Nakamura Y (2003). "Dual-specificity phosphatase 5 (DUSP5) as a direct transcriptional target of tumor suppressor p53.". Oncogene 22 (36): 5586-91. doi:10.1038/sj.onc.1206845. PMID 12944906.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Mandl M, Slack DN, Keyse SM (2005). "Specific inactivation and nuclear anchoring of extracellular signal-regulated kinase 2 by the inducible dual-specificity protein phosphatase DUSP5.". Mol. Cell. Biol. 25 (5): 1830-45. doi:10.1128/MCB.25.5.1830-1845.2005. PMID 15713638.
Jeong DG, Cho YH, Yoon TS, et al. (2007). "Crystal structure of the catalytic domain of human DUSP5, a dual specificity MAP kinase protein phosphatase.". Proteins 66 (1): 253-8. doi:10.1002/prot.21224. PMID 17078075.
Sarközi R, Miller B, Pollack V, et al. (2007). "ERK1/2-driven and MKP-mediated inhibition of EGF-induced ERK5 signaling in human proximal tubular cells.". J. Cell. Physiol. 211 (1): 88-100. doi:10.1002/jcp.20909. PMID 17131384.