DUSP22

From Wikipedia, the free encyclopedia

Dual specificity phosphatase 22

PDB rendering based on 1wrm.

Available structures: 1wrm

Identifiers

Symbol(s)

DUSP22; MKPX; JKAP; JSP1; VHX

External IDs

MGI: 1915926 HomoloGene: 86039

Gene ontology
Molecular Function:	• protein tyrosine phosphatase activity • protein tyrosine/serine/threonine phosphatase activity • hydrolase activity
Cellular Component:	• nucleus
Biological Process:	• inactivation of MAPK activity • protein amino acid dephosphorylation • apoptosis • multicellular organismal development • cell proliferation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

XM_001132925 (mRNA)
XP_001132925 (protein)

NM_001037955 (mRNA)
NP_001033044 (protein)

Location

Chr 6: 0.24 - 0.3 Mb

Chr 13: 30.67 - 30.72 Mb

Pubmed search

[1]

[2]

Dual specificity phosphatase 22, also known as DUSP22, is a human gene.^[1]

[edit] References

^ Entrez Gene: DUSP22 dual specificity phosphatase 22.

[edit] Further reading

Smith A, Price C, Cullen M, et al. (1997). "Chromosomal localization of three human dual specificity phosphatase genes (DUSP4, DUSP6, and DUSP7).". Genomics 42 (3): 524–7. doi:10.1006/geno.1997.4756. PMID 9205128.
Aoyama K, Nagata M, Oshima K, et al. (2001). "Molecular cloning and characterization of a novel dual specificity phosphatase, LMW-DSP2, that lacks the cdc25 homology domain.". J. Biol. Chem. 276 (29): 27575–83. doi:10.1074/jbc.M100408200. PMID 11346645.
Shen Y, Luche R, Wei B, et al. (2002). "Activation of the Jnk signaling pathway by a dual-specificity phosphatase, JSP-1.". Proc. Natl. Acad. Sci. U.S.A. 98 (24): 13613–8. doi:10.1073/pnas.231499098. PMID 11717427.
Alonso A, Merlo JJ, Na S, et al. (2002). "Inhibition of T cell antigen receptor signaling by VHR-related MKPX (VHX), a new dual specificity phosphatase related to VH1 related (VHR).". J. Biol. Chem. 277 (7): 5524–8. doi:10.1074/jbc.M107653200. PMID 11733513.
Chen AJ, Zhou G, Juan T, et al. (2002). "The dual specificity JKAP specifically activates the c-Jun N-terminal kinase pathway.". J. Biol. Chem. 277 (39): 36592–601. doi:10.1074/jbc.M200453200. PMID 12138158.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
Alonso A, Narisawa S, Bogetz J, et al. (2004). "VHY, a novel myristoylated testis-restricted dual specificity protein phosphatase related to VHX.". J. Biol. Chem. 279 (31): 32586–91. doi:10.1074/jbc.M403442200. PMID 15138252.
Fortna A, Kim Y, MacLaren E, et al. (2006). "Lineage-specific gene duplication and loss in human and great ape evolution.". PLoS Biol. 2 (7): E207. doi:10.1371/journal.pbio.0020207. PMID 15252450.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Yokota T, Nara Y, Kashima A, et al. (2007). "Crystal structure of human dual specificity phosphatase, JNK stimulatory phosphatase-1, at 1.5 A resolution.". Proteins 66 (2): 272–8. doi:10.1002/prot.21152. PMID 17068812.
Sekine Y, Ikeda O, Hayakawa Y, et al. (2007). "DUSP22/LMW-DSP2 regulates estrogen receptor-alpha-mediated signaling through dephosphorylation of Ser-118.". Oncogene 26 (41): 6038–49. doi:10.1038/sj.onc.1210426. PMID 17384676.