DUSP18

From Wikipedia, the free encyclopedia

Dual specificity phosphatase 18

PDB rendering based on 2esb.

Available structures: 2esb

Identifiers

Symbol(s)

DUSP18; DUSP20; LMWDSP20; MGC32658; bK963H5.1

External IDs

MGI: 1922469 HomoloGene: 34984

Gene ontology
Molecular Function:	• protein tyrosine phosphatase activity • protein tyrosine/serine/threonine phosphatase activity • hydrolase activity
Cellular Component:	• nucleus
Biological Process:	• protein amino acid dephosphorylation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_152511 (mRNA)
NP_689724 (protein)

NM_173745 (mRNA)
NP_776106 (protein)

Location

Chr 22: 29.39 - 29.39 Mb

Chr 11: 3.8 - 3.8 Mb

Pubmed search

[1]

[2]

Dual specificity phosphatase 18, also known as DUSP18, is a human gene.^[1]

[edit] References

^ Entrez Gene: DUSP18 dual specificity phosphatase 18.

[edit] Further reading

Wu Q, Huang S, Sun Y, et al. (2006). "Dual specificity phosphotase 18, interacting with SAPK, dephosphorylates SAPK and inhibits SAPK/JNK signal pathway in vivo.". Front. Biosci. 11: 2714-24. PMID 16720344.
Jeong DG, Cho YH, Yoon TS, et al. (2006). "Structure of human DSP18, a member of the dual-specificity protein tyrosine phosphatase family.". Acta Crystallogr. D Biol. Crystallogr. 62 (Pt 6): 582-8. doi:10.1107/S0907444906010109. PMID 16699184.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome.". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMID 15461802.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Wu Q, Gu S, Dai J, et al. (2003). "Molecular cloning and characterization of a novel dual-specificity phosphatase18 gene from human fetal brain.". Biochim. Biophys. Acta 1625 (3): 296-304. PMID 12591617.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Hood KL, Tobin JF, Yoon C (2002). "Identification and characterization of two novel low-molecular-weight dual specificity phosphatases.". Biochem. Biophys. Res. Commun. 298 (4): 545-51. PMID 12408986.