DUSP15

From Wikipedia, the free encyclopedia

Dual specificity phosphatase 15

PDB rendering based on 1yz4.

Available structures: 1yz4

Identifiers

Symbol(s)

DUSP15; VHY

External IDs

MGI: 1934928 HomoloGene: 33586

Gene ontology
Molecular Function:	• protein tyrosine phosphatase activity • protein tyrosine/serine/threonine phosphatase activity • hydrolase activity
Cellular Component:	• membrane
Biological Process:	• protein amino acid dephosphorylation

Orthologs

Human

Mouse

Refseq

NM_001012644 (mRNA)
NP_001012662 (protein)

NM_145744 (mRNA)
NP_665687 (protein)

Location

Chr 20: 29.9 - 29.92 Mb

Chr 2: 152.64 - 152.64 Mb

Pubmed search

[1]

[2]

Dual specificity phosphatase 15, also known as DUSP15, is a human gene.^[1]

The protein encoded by this gene belongs to the non-receptor class of the protein-tyrosine phosphatase family. The encoded protein has both protein-tyrosine phophatase activity and serine/threonine-specific phosphatase activity, and therefore is known as a dual specificity phosphatase. Three transcript variants encoding two different isoforms have been found for this gene.^[1]

[edit] References

^ ^a ^b Entrez Gene: DUSP15 dual specificity phosphatase 15.

[edit] Further reading

Yoon TS, Jeong DG, Kim JH, et al. (2006). "Crystal structure of the catalytic domain of human VHY, a dual-specificity protein phosphatase.". Proteins 61 (3): 694-7. doi:10.1002/prot.20642. PMID 16170801.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Alonso A, Narisawa S, Bogetz J, et al. (2004). "VHY, a novel myristoylated testis-restricted dual specificity protein phosphatase related to VHX.". J. Biol. Chem. 279 (31): 32586-91. doi:10.1074/jbc.M403442200. PMID 15138252.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20.". Nature 414 (6866): 865-71. doi:10.1038/414865a. PMID 11780052.
Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491-6. PMID 10737800.