DUSP10

From Wikipedia, the free encyclopedia

Dual specificity phosphatase 10

PDB rendering based on 1zzw.

Available structures: 1zzw

Identifiers

Symbol(s)

DUSP10; MKP-5; MKP5

External IDs

OMIM: 608867 MGI: 1927070 HomoloGene: 5215

Gene ontology
Molecular Function:	• protein tyrosine phosphatase activity • hydrolase activity • MAP kinase tyrosine/serine/threonine phosphatase activity
Cellular Component:	• nucleus • cytoplasm
Biological Process:	• protein amino acid dephosphorylation • response to stress • JNK cascade

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_007207 (mRNA)
NP_009138 (protein)

NM_022019 (mRNA)
NP_071302 (protein)

Location

Chr 1: 219.94 - 219.98 Mb

Chr 1: 185.74 - 185.78 Mb

Pubmed search

[1]

[2]

Dual specificity phosphatase 10, also known as DUSP10, is a human gene.^[1]

Dual specificity protein phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the MAPK superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of this family of dual specificity phosphatases show distinct substrate specificities for MAPKs, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product binds to and inactivates p38 and SAPK/JNK, but not MAPK/ERK. Its subcellular localization is unique; it is evenly distributed in both the cytoplasm and the nucleus. This gene is widely expressed in various tissues and organs, and its expression is elevated by stress stimuli. Three transcript variants encoding two different isoforms have been found for this gene.^[1]

[edit] References

^ ^a ^b Entrez Gene: DUSP10 dual specificity phosphatase 10.

[edit] Further reading

Martell KJ, Angelotti T, Ullrich A (1998). "The "VH1-like" dual-specificity protein tyrosine phosphatases.". Mol. Cells 8 (1): 2–11. PMID 9571625.
Teng CH, Huang WN, Meng TC (2007). "Several dual specificity phosphatases coordinate to control the magnitude and duration of JNK activation in signaling response to oxidative stress.". J. Biol. Chem. 282 (39): 28395–407. doi:10.1074/jbc.M705142200. PMID 17681939.
Tao X, Tong L (2007). "Crystal structure of the MAP kinase binding domain and the catalytic domain of human MKP5.". Protein Sci. 16 (5): 880–6. doi:10.1110/ps.062712807. PMID 17400920.
Nonn L, Duong D, Peehl DM (2007). "Chemopreventive anti-inflammatory activities of curcumin and other phytochemicals mediated by MAP kinase phosphatase-5 in prostate cells.". Carcinogenesis 28 (6): 1188–96. doi:10.1093/carcin/bgl241. PMID 17151092.
Jeong DG, Yoon TS, Kim JH, et al. (2006). "Crystal structure of the catalytic domain of human MAP kinase phosphatase 5: structural insight into constitutively active phosphatase.". J. Mol. Biol. 360 (5): 946–55. doi:10.1016/j.jmb.2006.05.059. PMID 16806267.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.
Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle.". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. doi:10.1073/pnas.0507066103. PMID 16565220.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Tanoue T, Yamamoto T, Maeda R, Nishida E (2001). "A Novel MAPK phosphatase MKP-7 acts preferentially on JNK/SAPK and p38 alpha and beta MAPKs.". J. Biol. Chem. 276 (28): 26629–39. doi:10.1074/jbc.M101981200. PMID 11359773.
Masuda K, Shima H, Kikuchi K, et al. (2000). "Expression and comparative chromosomal mapping of MKP-5 genes DUSP10/Dusp10.". Cytogenet. Cell Genet. 90 (1-2): 71–4. PMID 11060451.
Theodosiou A, Smith A, Gillieron C, et al. (2000). "MKP5, a new member of the MAP kinase phosphatase family, which selectively dephosphorylates stress-activated kinases.". Oncogene 18 (50): 6981–8. doi:10.1038/sj.onc.1203185. PMID 10597297.
Tanoue T, Moriguchi T, Nishida E (1999). "Molecular cloning and characterization of a novel dual specificity phosphatase, MKP-5.". J. Biol. Chem. 274 (28): 19949–56. PMID 10391943.