Talk:Duchenne muscular dystrophy

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Contents

[edit] Daughter's of men with Duchenne

The statement "Daughters of men with Duchenne also have a 50% chance of being carriers" seems to be completely wrong. Any female MUST get an X from her father, who only has 1 X, and if a man has Duchenne's than his 1 X must be infected. In other words, a daughter of a man with Duchenne, it seems to me, MUST be a carrier. I think that whoever wrote the statement got confused because the diagram shows an unaffected father, hence the chance that his daughter may not be a carrier.

--DreamsReign 22:57, 22 February 2006 (UTC)

Just noting that this has been fixed. --nkayesmith 01:36, 9 August 2006 (UTC)

[edit] Distal or proximal muscles?

Somebody changed the text Distal muscles to proximal muscles in symptoms section. Wikipedia mentions both on the page that proximal muscles redirects to, and I have it from a reliable source (which I should really put here) that the distal muscles are affected. However, upon reading wikipedia's explanation, I don't think either serve to cover all of the affected areas. Perhaps the somebody who changed this could leave an explanation here. Thanks. nkayesmith 01:58, 18 August 2006 (UTC)

As someone who suffers from the disease, I can tell you that all muscles are eventually affected. However, I'm not sure if proximal or distal muscles are affected first. As far as I know, they are affected at the same time. More accurately, voluntary muscles that aren't used while inactive or while sleeping deteriorate faster than involuntary muscles, such as cardiac muscles that are used all the time. For instance, I am 19 years old. I can't move my legs and can barely move my arms well enough to use a keyboard and mouse, but an ultrasound would reveal a healthy heart. Perhaps the text should be changed to voluntary muscles? --Sylvas 23:58, 26 February 2007 (UTC)

[edit] Possible references

From User talk:Nkayesmith:

Here are a few sources:
  • Emery, 2000, Muscular Dystrophy – The Facts, Oxford University Press, United States of America

NCurse work 13:59, 1 October 2006 (UTC)

[edit] Are there any specific racial groups or geographic areas in which DMD is more common?

I don't mean to sound racist or anything, but I'm doing a report on this disease and I can't find this info anywhere. Are there any specific racial groups or geographic areas in which DMD is more common? It would be really helpful if anyone knew this. --Floog 00:36, 26 March 2007 (UTC)

As am I, and I cannot find this information. It would be useful to have. GreaseNinja 14:23, 12 November 2007 (UTC)

[edit] muscle restoration in an animal model of Duchenne muscular dystrophy

Enough dystrophin accumulated in the muscles of the MD mice so that we could no longer find defects in the muscles when we examined them," says Sweeney (senior author H. Lee Sweeney, PhD, chair of the Department of Physiology at Penn). "For all intents and purposes the disease was corrected by treatment with PTC124." [1] Brian Pearson 05:03, 23 April 2007 (UTC)

NEJM - antisense oligonucleotide bridges open reading frame and induces dystrophin production. JFW | T@lk 07:51, 27 December 2007 (UTC)

[edit] Other Charities

http://www.actionduchenne.org/ - is a UK based Duchenne MD site, if non-US sites are wanted (though I know that it might make the list very long, if they were addded for all countries... hence not adding it myself. Emmadw (talk) 13:18, 19 April 2008 (UTC) Emma