DTX1

From Wikipedia, the free encyclopedia

Deltex homolog 1 (Drosophila)

Identifiers

DTX1; hDx-1

External IDs

OMIM: 602582 MGI: 1352744 HomoloGene: 74522

Gene ontology
Molecular Function:	• transcription coactivator activity • Notch binding • protein binding • zinc ion binding • transcription regulator activity • metal ion binding
Cellular Component:	• cytoplasm
Biological Process:	• transcription from RNA polymerase II promoter • regulation of Notch signaling pathway • glial cell differentiation • negative regulation of neuron differentiation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_004416 (mRNA)
NP_004407 (protein)

NM_008052 (mRNA)
NP_032078 (protein)

Location

Chr 12: 111.98 - 112.02 Mb

Chr 5: 120.94 - 120.97 Mb

Pubmed search

[1]

[2]

Deltex homolog 1 (Drosophila), also known as DTX1, is a human gene.^[1]

Studies in Drosophila have identified this gene as encoding a positive regulator of the Notch-signaling pathway. The human gene encodes a protein of unknown function; however, it may play a role in basic helix-loop-helix transcription factor activity.^[1]

[edit] References

^ ^a ^b Entrez Gene: DTX1 deltex homolog 1 (Drosophila).

[edit] Further reading

Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Saito T, Chiba S, Ichikawa M, et al. (2003). "Notch2 is preferentially expressed in mature B cells and indispensable for marginal zone B lineage development.". Immunity 18 (5): 675-85. PMID 12753744.
Takeyama K, Aguiar RC, Gu L, et al. (2003). "The BAL-binding protein BBAP and related Deltex family members exhibit ubiquitin-protein isopeptide ligase activity.". J. Biol. Chem. 278 (24): 21930-7. doi:10.1074/jbc.M301157200. PMID 12670957.
Gupta-Rossi N, Storck S, Griebel PJ, et al. (2003). "Specific over-expression of deltex and a new Kelch-like protein in human germinal center B cells.". Mol. Immunol. 39 (13): 791-9. PMID 12617994.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Izon DJ, Aster JC, He Y, et al. (2002). "Deltex1 redirects lymphoid progenitors to the B cell lineage by antagonizing Notch1.". Immunity 16 (2): 231-43. PMID 11869684.
Yamamoto N, Yamamoto S, Inagaki F, et al. (2002). "Role of Deltex-1 as a transcriptional regulator downstream of the Notch receptor.". J. Biol. Chem. 276 (48): 45031-40. doi:10.1074/jbc.M105245200. PMID 11564735.
Kishi N, Tang Z, Maeda Y, et al. (2001). "Murine homologs of deltex define a novel gene family involved in vertebrate Notch signaling and neurogenesis.". Int. J. Dev. Neurosci. 19 (1): 21-35. PMID 11226752.
Lee L, Dowhanick-Morrissette J, Katz A, et al. (2001). "Chromosomal localization, genomic characterization, and mapping to the Noonan syndrome critical region of the human Deltex (DTX1) gene.". Hum. Genet. 107 (6): 577-81. PMID 11153911.
Matsuno K, Eastman D, Mitsiades T, et al. (1998). "Human deltex is a conserved regulator of Notch signalling.". Nat. Genet. 19 (1): 74-8. doi:10.1038/ng0598-74. PMID 9590294.
Blaumueller CM, Qi H, Zagouras P, Artavanis-Tsakonas S (1997). "Intracellular cleavage of Notch leads to a heterodimeric receptor on the plasma membrane.". Cell 90 (2): 281-91. PMID 9244302.
Matsuno K, Diederich RJ, Go MJ, et al. (1995). "Deltex acts as a positive regulator of Notch signaling through interactions with the Notch ankyrin repeats.". Development 121 (8): 2633-44. PMID 7671825.