DTDP-galactose 6-dehydrogenase

From Wikipedia, the free encyclopedia

In enzymology, a dTDP-galactose 6-dehydrogenase (EC 1.1.1.186) is an enzyme that catalyzes the chemical reaction

dTDP-D-galactose + 2 NADP⁺ + H₂O dTDP-D-galacturonate + 2 NADPH + 2 H⁺

The 3 substrates of this enzyme are dTDP-D-galactose, NADP⁺, and H₂O, whereas its 3 products are dTDP-D-galacturonate, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is dTDP-D-galactose:NADP+ 6-oxidoreductase. This enzyme is also called thymidine-diphosphate-galactose dehydrogenase. This enzyme participates in nucleotide sugars metabolism.

[edit] References

• IUBMB entry for 1.1.1.186
• BRENDA references for 1.1.1.186 (Recommended.)
• PubMed references for 1.1.1.186
• PubMed Central references for 1.1.1.186
• Google Scholar references for 1.1.1.186
• Katan R, Avigad G (1966). "NADP dependent oxidation of TDP-glucose by an enzyme system from sugar beets". Biochem. Biophys. Res. Commun. 24: 18–24. doi:10.1016/0006-291X(66)90403-7. PMID 4381717. 

[edit] External links

• IUBMB entry for 1.1.1.186

• KEGG entry for 1.1.1.186

• BRENDA entry for 1.1.1.186

• NiceZyme view of 1.1.1.186

• EC2PDB: PDB structures for 1.1.1.186

• PRIAM entry for 1.1.1.186

• PUMA2 entry for 1.1.1.186

• IntEnz: Integrated Enzyme entry for 1.1.1.186

• MetaCyc entry for 1.1.1.186

• Atomic-resolution structures of enzymes belonging to this class