DSE (gene)

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Dermatan sulfate epimerase
Identifiers
Symbol(s) DSE; DSEPI; SART2
External IDs OMIM: 605942 MGI: 2443455 HomoloGene: 8354
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 29940 212898
Ensembl ENSG00000111817 ENSMUSG00000039497
Uniprot Q9UL01 Q8BLI4
Refseq NM_001080976 (mRNA)
NP_001074445 (protein)		 NM_172508 (mRNA)
NP_766096 (protein)
Location Chr 6: 116.71 - 116.87 Mb Chr 10: 33.84 - 33.9 Mb
Pubmed search [1] [2]

Dermatan sulfate epimerase, also known as DSE, is a human gene.[1]

The protein encoded by this gene is a tumor-rejection antigen. This antigen possesses tumor epitopes capable of inducing HLA-A24-restricted and tumor-specific cytotoxic T lymphocytes in cancer patients and may be useful for specific immunotherapy. This gene product is localized to the endoplasmic reticulum. Two transcript variants encoding the same protein have been found for this gene.[1]

[edit] References

  1. ^ a b Entrez Gene: DSE dermatan sulfate epimerase.

[edit] Further reading

  • Nakao M, Shichijo S, Imaizumi T, et al. (2000). "Identification of a gene coding for a new squamous cell carcinoma antigen recognized by the CTL.". J. Immunol. 164 (5): 2565-74. PMID 10679095. 
  • Tanaka S, Tsuda N, Kawano K, et al. (2001). "Expression of tumor-rejection antigens in gynecologic cancers.". Jpn. J. Cancer Res. 91 (11): 1177-84. PMID 11092984. 
  • Sasatomi T, Suefuji Y, Matsunaga K, et al. (2002). "Expression of tumor rejection antigens in colorectal carcinomas.". Cancer 94 (6): 1636-41. PMID 11920522. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805-11. doi:10.1038/nature02055. PMID 14574404. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55-65. doi:10.1101/gr.4039406. PMID 16344560. 
  • Maccarana M, Olander B, Malmström J, et al. (2006). "Biosynthesis of dermatan sulfate: chondroitin-glucuronate C5-epimerase is identical to SART2.". J. Biol. Chem. 281 (17): 11560-8. doi:10.1074/jbc.M513373200. PMID 16505484. 
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