DSC3

From Wikipedia, the free encyclopedia

Desmocollin 3

Identifiers

DSC3; DSC1; DSC2; CDHF3; DSC; DSC4; HT-CP

External IDs

OMIM: 600271 MGI: 1194993 HomoloGene: 1462

Gene ontology
Molecular Function:	• calcium ion binding • protein binding
Cellular Component:	• membrane fraction • cytoskeleton • plasma membrane • intercellular junction • integral to membrane
Biological Process:	• cell adhesion • homophilic cell adhesion

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001941 (mRNA)
NP_001932 (protein)

NM_007882 (mRNA)
NP_031908 (protein)

Location

Chr 18: 26.83 - 26.88 Mb

Chr 18: 20.11 - 20.15 Mb

Pubmed search

[1]

[2]

Desmocollin 3, also known as DSC3, is a human gene.^[1]

The protein encoded by this gene is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation. The desmosomal family members are arranged in two clusters on chromosome 18, occupying less than 650 kb combined. Alternative splicing results in two transcript variants encoding distinct isoforms.^[1]

[edit] References

^ ^a ^b Entrez Gene: DSC3 desmocollin 3.

[edit] Further reading

Buxton RS, Cowin P, Franke WW, et al. (1993). "Nomenclature of the desmosomal cadherins.". J. Cell Biol. 121 (3): 481–3. PMID 8486729.
Arnemann J, Spurr NK, Wheeler GN, et al. (1991). "Chromosomal assignment of the human genes coding for the major proteins of the desmosome junction, desmoglein DGI (DSG), desmocollins DGII/III (DSC), desmoplakins DPI/II (DSP), and plakoglobin DPIII (JUP).". Genomics 10 (3): 640–5. PMID 1889810.
King IA, Sullivan KH, Bennett R, Buxton RS (1995). "The desmocollins of human foreskin epidermis: identification and chromosomal assignment of a third gene and expression patterns of the three isoforms.". J. Invest. Dermatol. 105 (3): 314–21. PMID 7665906.
Amagai M, Wang Y, Minoshima S, et al. (1995). "Assignment of the human genes for desmocollin 3 (DSC3) and desmocollin 4 (DSC4) to chromosome 18q12.". Genomics 25 (1): 330–2. PMID 7774948.
Kawamura K, Watanabe K, Suzuki T, et al. (1994). "cDNA cloning and expression of a novel human desmocollin.". J. Biol. Chem. 269 (42): 26295–302. PMID 7929347.
Buxton RS, Wheeler GN, Pidsley SC, et al. (1994). "Mouse desmocollin (Dsc3) and desmoglein (Dsg1) genes are closely linked in the proximal region of chromosome 18.". Genomics 21 (3): 510–6. doi:10.1006/geno.1994.1309. PMID 7959727.
Nuber UA, Schäfer S, Stehr S, et al. (1997). "Patterns of desmocollin synthesis in human epithelia: immunolocalization of desmocollins 1 and 3 in special epithelia and in cultured cells.". Eur. J. Cell Biol. 71 (1): 1–13. PMID 8884173.
Kurzen H, Moll I, Moll R, et al. (1998). "Compositionally different desmosomes in the various compartments of the human hair follicle.". Differentiation 63 (5): 295–304. PMID 9810708.
Moll I, Houdek P, Schäfer S, et al. (1999). "Diversity of desmosomal proteins in regenerating epidermis: immunohistochemical study using a human skin organ culture model.". Arch. Dermatol. Res. 291 (7-8): 437–46. PMID 10482015.
Hanakawa Y, Amagai M, Shirakata Y, et al. (2000). "Different effects of dominant negative mutants of desmocollin and desmoglein on the cell-cell adhesion of keratinocytes.". J. Cell. Sci. 113 ( Pt 10): 1803–11. PMID 10769211.
Whittock NV, Hunt DM, Rickman L, et al. (2000). "Genomic organization and amplification of the human desmosomal cadherin genes DSC1 and DSC3, encoding desmocollin types 1 and 3.". Biochem. Biophys. Res. Commun. 276 (2): 454–60. doi:10.1006/bbrc.2000.3500. PMID 11027496.
Gadhavi PL, Greenwood MD, Strom M, et al. (2001). "The regulatory region of the human desmocollin 3 promoter forms a DNA four-way junction.". Biochem. Biophys. Res. Commun. 281 (2): 520–8. doi:10.1006/bbrc.2001.4375. PMID 11181078.
Klus GT, Rokaeus N, Bittner ML, et al. (2001). "Down-regulation of the desmosomal cadherin desmocollin 3 in human breast cancer.". Int. J. Oncol. 19 (1): 169–74. PMID 11408939.
Weiske J, Schöneberg T, Schröder W, et al. (2001). "The fate of desmosomal proteins in apoptotic cells.". J. Biol. Chem. 276 (44): 41175–81. doi:10.1074/jbc.M105769200. PMID 11500511.
Hatzfeld M, Green KJ, Sauter H (2003). "Targeting of p0071 to desmosomes and adherens junctions is mediated by different protein domains.". J. Cell. Sci. 116 (Pt 7): 1219–33. PMID 12615965.
Bonné S, Gilbert B, Hatzfeld M, et al. (2003). "Defining desmosomal plakophilin-3 interactions.". J. Cell Biol. 161 (2): 403–16. doi:10.1083/jcb.200303036. PMID 12707304.
Oshiro MM, Watts GS, Wozniak RJ, et al. (2003). "Mutant p53 and aberrant cytosine methylation cooperate to silence gene expression.". Oncogene 22 (23): 3624–34. doi:10.1038/sj.onc.1206545. PMID 12789271.
Zhang Y, Wolf-Yadlin A, Ross PL, et al. (2005). "Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules.". Mol. Cell Proteomics 4 (9): 1240–50. doi:10.1074/mcp.M500089-MCP200. PMID 15951569.
Oshiro MM, Kim CJ, Wozniak RJ, et al. (2006). "Epigenetic silencing of DSC3 is a common event in human breast cancer.". Breast Cancer Res. 7 (5): R669–80. doi:10.1186/bcr1273. PMID 16168112.