Talk:Dronabinol

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[edit] Unsourced statements re immunosuppressive effect

Could someone shed some light on this? It hardly seems likely that this drug would be used in AIDS and chemotherapy if it had immunosuppressive properties. That's a pretty serious statement to leave unsourced in the article. Zuiram 11:42, 22 February 2007 (UTC)

Added a reference and there is more serious stuff about THC and immunosupressive effects but not enough space here -- Panoramix303 18:52, 3 November 2007 (UTC)

[edit] misc

This article is currently terrible--it's heavily biased against the drug, refers to marijuana as "medicine," and spells "ingested" as "injested." No comment.

Marijuana is legal in 13 states and in quite a few other countries for medicinal purposes, and there are currently two prescription THC-based medications legally available in America, Marinol (dronabinol) and Cesamet (nabilone). Marijuana is medicine when dosed properly, when taken too much or abused it is a recreational drug, just like with Xanax or Oxycontin or any other drug, if dosed properly and according to a doctor's recommendations it's a medicine but when you overdose and abuse a drug it isn't medicinal , its recreational.


I would like to consider contributing to this page by adding how Marinol is taken (orally) and how it interacts with the patients system in comparison to regular marijuana, and the positives of the synthetic pill.--Amichs 14:46, 23 September 2005 (UTC)

   -- So do it.  It's wikipedia, no one is stopping you.

Also some information could be added on the possibility of smoking Marinol. I have no sources to cite but personal experience, but I have broken open the capsules, squeezed the oil onto cannabis plant material and smoked that together. Some people seem to think you can't smoke it because it is a liquid, or that there is something in it that would be bad for you. Hmm, how would I cite myself as a source. Maybe I'll go make a video on YouTube and reference that, hahaha...--Quickmythril 14:25, 18 October 2006 (UTC)

This article seems very US based; Marinol is also available in Canada. - Andrew (AJJ), 1 November 2005

[edit] Also for opiate addicts

Doctors are now presribing Marinol to treat patients going through medically assisted heroin detoxification. I know it for a fact, because I hold the bottle in my hand now

I also have Marinol Rx'd (10mg, T.I.D.) and had it when i was on suboxone as well, used it for nausea, appetite stimulation, weight gain, insomnia, anxiety, etc.

[edit] I love spurious "information"

"Many users complain that not only is the cost of Marinol greater than the cost of the amount of marijuana needed to produce the same effect, but it is also lacking in many of the properties of the whole plant, which contains hundreds of different cannabinoids."

...of which the only one proven to reduce nausea is the one used in Marinol. Marinol is actually quite the wonder drug, and very cheap for what it does. Doctors in Canada prescribe it all the time; American doctors would love to. When doctors are surveyed about medical marijuana they are generally talking about the THC replicated in Marinol, not smoking a plant with wildly varying degrees of chemicals. The medical community has long since embraced the benefits of certain cannabinoids.. just like they have long since embraced the uses of many opiates. And just like a doctor would not recommend you go smoke black tar opium for your sore back, they are not suggesting you smoke unprocessed plants.

The medical community has known about the benefits YEARS before High Times and later NORML latched onto it. Let's be honest... this statement pretty much sums it up:

"Cannabis is a natural source of dronabinol (THC), the ingredient of Marinol™, a Schedule III drug. There are no grounds to schedule cannabis in a more restrictive schedule than Marinol™""

.... yes, there are. Marijuana gets you high. Marinol doesn't. What is WITH that prevailing line of illogic; and why is it given credibility here? Quit the politics and just come out and say you want to be able to legally get high. People should try it more. Honesty really IS the best policy. A little less doublespeak and a little more knowledge from actual MEDICAL DOCTORS lay the truth to bear.

Actually, marinol is highly psycho-active, which is another common complaint from Marinol users -- more psycho-active, in fact, than real marijuana. If medical marijuana proponents just wanted to get high, marinol would be the route to take. FYI, the lack of chemical complexity really is one of the downfalls of marinol. It lacks cannabidiol (CBD), thought to be the major anti-convulsant that helps ms patients, and cannabichromine (CBC), an anti-inflammatory which may be responsible for much of the pain-killing effect of marijuana. Dilvie 10:59, 27 July 2006 (UTC)
First of all in this article it says: Some patients accustomed to inhaling just enough cannabis smoke to manage symptoms have complained of too-intense intoxication via Marinol's predetermined dosages. This powerful psychoactive effect, however, has led to recreational use of Marinol.[1] Many have said that Marinol produces a more acute psychedelic effect than cannabis and it has been speculated that this disparity can be explained by the moderating effect of the many non-THC cannibinoids present in cannabis.
Marijuana is less of a high than Marinol because it contains other cannabinoids, specifically CBD which lessens the euphoric effects of THC (Read about it on wikipedia's CBD page). CBD is the second most prevalent cannabinoid in marijuana. I know from years of experience 10 with cannabis, and 3 with marinol that both can get you high and marniol can make you hallucinate at high doses (40-50mg) and it is stronger than marijuana and you can more "intoxicated" if you want to use that word. this is honesty, you obviously don't know or don't have any experience with cannabis/marinol. person who wrote "Marijuana gets you high Marinol doesn't." Chq (talk) 16:04, 18 May 2008 (UTC)

[edit] Page is very POV, FUBAR'd

Someone really messed up the formatting to this page. It seems that the quote areas don't wrap? Yes, it seems a user Ttblythe did this. Seems crossposted from somewhere? Thatfunkymunki 06:44, 12 June 2006 (UTC)

After reviewing the addition, I ended up removing the new section. The main reason is because the addition violates the original work policy (it's a creation with a thesis), and is POV (it even uses the first-person singular voice). As a student and researcher, I also found the analysis of the studies cited to be highly problematic. Oasisbob 05:19, 14 June 2006 (UTC)

[edit] Information on production?

I always hear dronabinol called "synthetic" THC.. can anyone provide any information on how it is produced? I can't imagine it's fully synthetic.. I wouldn't be surpised if it's more like an extraction or something. Cheers --Frantik 08:53, 5 September 2006 (UTC)

its an analogue to THC. Chq 01:21, 24 September 2006 (UTC)
It is not an analog to THC. Two chemical compounds which are the same cannot be an analog, simply by definition. To answer the original question, Marinol contains THC synthesized chemically, not extracted. I'd imagine that there are regulatory reasons behind this decision. Oasisbob 21:24, 9 December 2006 (UTC)
Actually dronabinol is extracted from cannabis. read the top of the marinol (dronabinol page) here on wikipedia. "Dronabinol, sold as Marinol (a registered trademark of Solvay Pharmaceuticals, Inc.), is the International Nonproprietary Name (INN) of Δ9-tetrahydrocannabinol (THC). THC is a naturally occurring component in cannabis. While THC is the main psychoactive substance in cannabis, dronabinol preparations do not contain the other significant chemical constituents present in cannabis."

Cesamet (nabilone) is a synthetic cannabinoid. and "Nabilone is not derived from the cannabis plant as is dronabinol." - from the nabilone wiki page.

here's what it says on marinol's patient information packet: MARINOL ® Capsules contains man-made dronabinol (THC). Dronabinol also occurs naturally, and has been extracted from Cannabis sativa L. (marijuana). 69.125.138.8 (talk) 17:25, 18 May 2008 (UTC)

[edit] Un-POVing this page

I added the section header, "Comparisons to medicinal cannabis" to try to isolate the troubled language. In this section, I have tried to simplify, componentize, and de-POV the disputed languge. I did, however, add a verify tag. If people have made those claims, let's get 'em sourced! We definately need to find some statements made by people who prefer Marinol to cannabis. Another idea - if it can't be easily done, change the section header to "Criticisms of Marinol" and work on that premise.

--66.233.54.205 23:48, 11 January 2007 (UTC)

[edit] Move to Dronabinol

this chemical is the same thing as normal THC except it is synthesised in a lab, not a Cannabis plant, but marinol is a proprietry name, but Dronabinol is the chemical name for synthetic THC, so I'm moving this article to Dronabinol. —The preceding unsigned comment was added by The Right Honourable (talk • contribs) 07:41, 12 February 2007 (UTC).

Please go ahead and do so. Currently, dronabinol redirects here, which is inconsistent with the current policy of having the proprietary names redirect to the INN version, even when there is only one proprietary formulation available. Zuiram 11:39, 22 February 2007 (UTC)


[edit] Tried the 5 mg yesterday

I tried the 5 mg capsule yesterday -- I was very high for 5 hours or so -- and it was a nice high, not the same as smoking cannabis IMO, and when coming down I wans't tired at all. I don't think the 10 mg would be much fun. On a side note it didn't increase appetite. —The preceding unsigned comment was added by 70.230.222.98 (talk) 23:48, 23 February 2007 (UTC).


Didn't increase appetite, are you kidding? I've been prescribed the 2.5mg capsules, the 5mg and the 10mg, am Rx'd 10mg 2x a day currently and at every dose i've taken from 2.5-50mg a day, i've noticed increase in appetite, and at the higher doses a euphoria/high and strong sedation/body relaxation, definitely not the same as smoking because you're missing 59 or so other active cannabinoids that you get when you smoke/vaporize/eat/drink cannabis. —Preceding unsigned comment added by Chq (talk • contribs) 16:16, 18 May 2008 (UTC)

[edit] Why 2 articles?

Why are there 2 articles (Tetrahydrocannabinol and Dronabinol) on one and the same substance?? And btw, the molecule shown is actually the enantiomer of THC - is dronabinol a mixture of THC and its enantiomer? Icek 07:18, 2 August 2007 (UTC)

THC is the active ingredient in both Marinol (dronabinol) and in cannabis which is why there are two articles. Marinol is completely different than THC in regards to having a page on wikipedia, merging them would make no sense, that would be like merging the THC thread with hash or marijuana... —Preceding unsigned comment added by Chq (talk • contribs) 16:19, 18 May 2008 (UTC)

[edit] Some changes

Dronabinol is the INN of delta9-THC and nothing else. I change the incorrect information that it is an enantiomer. A short click on the CAS no should solve this riddle. A reference was added to immunosupressive effects and the picture was change. It showed the wrong isomer. -- Panoramix303 18:52, 3 November 2007 (UTC)

[edit] Metabolism

The metabolism section was recently changed and contradicts the information given in tetrahydrocannabinol. In the dronabinol article the half life is 25-36 hours and in the excretion renal vs. 1.6-59 hours and mostly fecal in the THC article. No offense to NORML but I think Marylin Huestis is the expert in the field. If no one objects I will change the dronabinol article. -- 18:44, 18 May 2008 (UTC) -- Panoramix303 (talk) 16:51, 19 May 2008 (UTC)