DRG2

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Developmentally regulated GTP binding protein 2
Identifiers
Symbol(s) DRG2;
External IDs OMIM: 602986 MGI: 1342307 HomoloGene: 1061
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 1819 13495
Ensembl ENSG00000108591 ENSMUSG00000020537
Uniprot P55039 Q5SX94
Refseq NM_001388 (mRNA)
NP_001379 (protein)		 NM_021354 (mRNA)
NP_067329 (protein)
Location Chr 17: 17.93 - 17.95 Mb Chr 11: 60.27 - 60.28 Mb
Pubmed search [1] [2]

Developmentally regulated GTP binding protein 2, also known as DRG2, is a human gene.[1]

The DRG2 gene encodes the developmentally regulated GTP-binding protein 2, a name derived from the fact that it shares significant similarity to known GTP-binding proteins. DRG2 was identified because it is expressed in normal fibroblasts but not in SV40-transformed fibroblasts. Read-through transcripts containing this gene and a downstream gene have been identified, but they are not thought to encode a fusion protein. This gene is located within the Smith-Magenis syndrome region on chromosome 17.[1]

[edit] References

  1. ^ a b Entrez Gene: DRG2 developmentally regulated GTP binding protein 2.

[edit] Further reading

  • Sprang SR (1998). "G proteins, effectors and GAPs: structure and mechanism.". Curr. Opin. Struct. Biol. 7 (6): 849–56. PMID 9434906. 
  • Schenker T, Lach C, Kessler B, et al. (1994). "A novel GTP-binding protein which is selectively repressed in SV40 transformed fibroblasts.". J. Biol. Chem. 269 (41): 25447–53. PMID 7929244. 
  • Schenker T, Trueb B (1998). "Assignment of the gene for a developmentally regulated GTP-binding protein (DRG2) to human chromosome bands 17p13-->p12 by in situ hybridization.". Cytogenet. Cell Genet. 79 (3-4): 274–5. PMID 9605870. 
  • Liang Y, Wang A, Belyantseva IA, et al. (2000). "Characterization of the human and mouse unconventional myosin XV genes responsible for hereditary deafness DFNB3 and shaker 2.". Genomics 61 (3): 243–58. doi:10.1006/geno.1999.5976. PMID 10552926. 
  • Li B, Trueb B (2000). "DRG represents a family of two closely related GTP-binding proteins.". Biochim. Biophys. Acta 1491 (1-3): 196–204. PMID 10760581. 
  • Vlangos CN, Das P, Patel PI, Elsea SH (2000). "Assignment of developmentally regulated GTP-binding protein (DRG2) to human chromosome band 17p11.2 with somatic cell hybrids and localization to the Smith-Magenis syndrome critical interval.". Cytogenet. Cell Genet. 88 (3-4): 283–5. PMID 10828610. 
  • Bi W, Yan J, Stankiewicz P, et al. (2002). "Genes in a refined Smith-Magenis syndrome critical deletion interval on chromosome 17p11.2 and the syntenic region of the mouse.". Genome Res. 12 (5): 713–28. doi:10.1101/gr.73702. PMID 11997338. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Song H, Kim SI, Ko MS, et al. (2005). "Overexpression of DRG2 increases G2/M phase cells and decreases sensitivity to nocodazole-induced apoptosis.". J. Biochem. 135 (3): 331–5. PMID 15113831. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
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