Talk:Dosulepin hydrochloride

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[edit] Dosulepin vs. dothiepin

Anybody know why dothiepin was renamed to dosulepin? I'm of the impression that dothiepin was the prevalent name, and changing it seems to have caused some amount of confusion. Chris 22:47, 7 July 2006 (UTC)

Its original name was and is dosulepin, it was developed under this trivial name in the former Czechoslovakia back in the 1960's as a derivative of amitriptyline.--Spiperon 22:11, 15 October 2006 (UTC)

[edit] Cardiotoxicity

I've heard claims that dothiepin is particularly cardiotoxic at doses not massively higher than what might be prescribed for theraputic use. Anybody know if this is true, and if so, is it worth mentioning in the article? Chris 22:47, 7 July 2006 (UTC)

Well, every anticholinergic TCA is cardiotoxic above the maximal daily dose. As dosulepin is quite anticholinergic (not as much as amitriptyline, but more than desipramine), it is cardiotoxic in higher doses. But not particulary. Amitriptyline, in this respect, is somewhat worse.--Spiperon 22:13, 15 October 2006 (UTC)