Dopamine receptor D1

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The correct title of this article is Dopamine receptor D1. It appears incorrectly here because of technical restrictions.


Dopamine receptor D1
Identifiers
Symbol(s) DRD1; DADR; DRD1A
External IDs OMIM: 126449 MGI: 99578 HomoloGene: 30992
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 1812 13488
Ensembl ENSG00000184845 ENSMUSG00000021478
Uniprot P21728 Q80T33
Refseq NM_000794 (mRNA)
NP_000785 (protein)		 NM_010076 (mRNA)
NP_034206 (protein)
Location Chr 5: 174.8 - 174.8 Mb Chr 13: 54.06 - 54.07 Mb
Pubmed search [1] [2]

Dopamine receptor D1, also known as DRD1, is a human gene.

This gene encodes the D1 subtype of the dopamine receptor. The D1 subtype is the most abundant dopamine receptor in the central nervous system. This G-protein coupled receptor stimulates adenylyl cyclase and activates cyclic AMP-dependent protein kinases. D1 receptors regulate neuronal growth and development, mediate some behavioral responses, and modulate dopamine receptor D2-mediated events. Alternate transcription initiation sites result in two transcript variants of this gene.[1]

Contents

[edit] Ligands

  • (+)-trans-2,3-dihydroxy-6a,7,8,12b-tetrahydro-6H-chromeno[3,4-c]isoquinoline, a chromano (oxygen) bioisostere of dihydrexidine, potent full agonist, selective over D2[2]
  • A-86929, full agonist[3][4]
Chemical structures of selective D1 receptor agonists.
Chemical structures of selective D1 receptor agonists.[2][3]


[edit] See also

[edit] References

  1. ^ Entrez Gene: DRD1 dopamine receptor D1.
  2. ^ a b Cueva JP, Giorgioni G, Grubbs RA, Chemel BR, Watts VJ, Nichols DE (2006). "trans-2,3-dihydroxy-6a,7,8,12b-tetrahydro-6H-chromeno[3,4-c]isoquinoline: synthesis, resolution, and preliminary pharmacological characterization of a new dopamine D1 receptor full agonist". J. Med. Chem. 49 (23): 6848–57. doi:10.1021/jm0604979. PMID 17154515. 
  3. ^ a b Michaelides MR, Hong Y, DiDomenico S, Asin KE, Britton DR, Lin CW, Williams M, Shiosaki K (1995). "(5aR,11bS)-4,5,5a,6,7,11b-hexahydro-2-propyl-3-thia-5-azacyclopent-1- ena[c]-phenanthrene-9,10-diol (A-86929): a potent and selective dopamine D1 agonist that maintains behavioral efficacy following repeated administration and characterization of its diacetyl prodrug (ABT-431)". J. Med. Chem. 38 (18): 3445–7. doi:10.1021/jm00018a002. PMID 7658429. 
  4. ^ Yamashita M, Yamada K, Tomioka K (2004). "Construction of arene-fused-piperidine motifs by asymmetric addition of 2-trityloxymethylaryllithiums to nitroalkenes: the asymmetric synthesis of a dopamine D1 full agonist, A-86929". J. Am. Chem. Soc. 126 (7): 1954–5. doi:10.1021/ja031760n. PMID 14971926. 

[edit] Further reading

  • Missale C, Nash SR, Robinson SW, et al. (1998). "Dopamine receptors: from structure to function.". Physiol. Rev. 78 (1): 189–225. PMID 9457173. 
  • Milligan G, White JH (2001). "Protein-protein interactions at G-protein-coupled receptors.". Trends Pharmacol. Sci. 22 (10): 513–8. PMID 11583808. 
  • Bermak JC, Zhou QY (2004). "Accessory proteins in the biogenesis of G protein-coupled receptors.". Mol. Interv. 1 (5): 282–7. PMID 14993367. 
  • Minowa MT, Minowa T, Monsma FJ, et al. (1992). "Characterization of the 5' flanking region of the human D1A dopamine receptor gene.". Proc. Natl. Acad. Sci. U.S.A. 89 (7): 3045–9. PMID 1557411. 
  • Tiberi M, Jarvie KR, Silvia C, et al. (1991). "Cloning, molecular characterization, and chromosomal assignment of a gene encoding a second D1 dopamine receptor subtype: differential expression pattern in rat brain compared with the D1A receptor.". Proc. Natl. Acad. Sci. U.S.A. 88 (17): 7491–5. PMID 1831904. 
  • Sunahara RK, Niznik HB, Weiner DM, et al. (1990). "Human dopamine D1 receptor encoded by an intronless gene on chromosome 5.". Nature 347 (6288): 80–3. doi:10.1038/347080a0. PMID 1975640. 
  • Grandy DK, Zhou QY, Allen L, et al. (1990). "A human D1 dopamine receptor gene is located on chromosome 5 at q35.1 and identifies an EcoRI RFLP.". Am. J. Hum. Genet. 47 (5): 828–34. PMID 1977312. 
  • Dearry A, Gingrich JA, Falardeau P, et al. (1990). "Molecular cloning and expression of the gene for a human D1 dopamine receptor.". Nature 347 (6288): 72–6. doi:10.1038/347072a0. PMID 2144334. 
  • Zhou QY, Grandy DK, Thambi L, et al. (1990). "Cloning and expression of human and rat D1 dopamine receptors.". Nature 347 (6288): 76–80. doi:10.1038/347076a0. PMID 2168520. 
  • Frail DE, Manelli AM, Witte DG, et al. (1994). "Cloning and characterization of a truncated dopamine D1 receptor from goldfish retina: stimulation of cyclic AMP production and calcium mobilization.". Mol. Pharmacol. 44 (6): 1113–8. PMID 8264547. 
  • Ohara K, Ulpian C, Seeman P, et al. (1993). "Schizophrenia: dopamine D1 receptor sequence is normal, but has DNA polymorphisms.". Neuropsychopharmacology 8 (2): 131–5. PMID 8471124. 
  • Albrecht FE, Drago J, Felder RA, et al. (1996). "Role of the D1A dopamine receptor in the pathogenesis of genetic hypertension.". J. Clin. Invest. 97 (10): 2283–8. PMID 8636408. 
  • Lee SH, Minowa MT, Mouradian MM (1996). "Two distinct promoters drive transcription of the human D1A dopamine receptor gene.". J. Biol. Chem. 271 (41): 25292–9. PMID 8810292. 
  • Mayerhofer A, Hemmings HC, Snyder GL, et al. (1999). "Functional dopamine-1 receptors and DARPP-32 are expressed in human ovary and granulosa luteal cells in vitro.". J. Clin. Endocrinol. Metab. 84 (1): 257–64. PMID 9920093. 
  • Wong AC, Shetreat ME, Clarke JO, Rayport S (1999). "D1- and D2-like dopamine receptors are co-localized on the presynaptic varicosities of striatal and nucleus accumbens neurons in vitro.". Neuroscience 89 (1): 221–33. PMID 10051231. 
  • Jin H, Xie Z, George SR, O'Dowd BF (2000). "Palmitoylation occurs at cysteine 347 and cysteine 351 of the dopamine D(1) receptor.". Eur. J. Pharmacol. 386 (2-3): 305–12. PMID 10618483. 
  • Li M, Bermak JC, Wang ZW, Zhou QY (2000). "Modulation of dopamine D(2) receptor signaling by actin-binding protein (ABP-280).". Mol. Pharmacol. 57 (3): 446–52. PMID 10692483. 
  • Lezcano N, Mrzljak L, Eubanks S, et al. (2000). "Dual signaling regulated by calcyon, a D1 dopamine receptor interacting protein.". Science 287 (5458): 1660–4. PMID 10698743. 
  • Ginés S, Hillion J, Torvinen M, et al. (2000). "Dopamine D1 and adenosine A1 receptors form functionally interacting heteromeric complexes.". Proc. Natl. Acad. Sci. U.S.A. 97 (15): 8606–11. doi:10.1073/pnas.150241097. PMID 10890919. 

[edit] External links

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v • d • e
Transmembrane receptor: G protein-coupled receptors
Class A: Rhodopsin like
Acetylcholine (M1, M2, M3, M4, M5) - Adrenergic (α1 (A, B, D), α2 (A, B, C), β1, β2, β3) - Adrenomedullin - Anaphylatoxin (C3a, C5a) - Angiotensin (1, 2) - Apelin - Bile acid - Bombesin (BRS3, GRPR, NMBR) - Bradykinin (B1, B2) - Cannabinoid (CB1, CB2) - Chemokine - Cholecystokinin (A, B) - Dopamine (D1, D2, D3, D4, D5) - Eicosanoid (CysLT (1, 2), LTB4 (1, 2), FPRL1, OXE, Prostaglandin ((DP (1, 2), EP (1, 2, 3, 4), PGF, Prostacyclin, Thromboxane) - EBI2 - Endothelin (A, B) - Estrogen - Formyl peptide (1, L1, L2) - Free fatty acid (1, 2, 3, 4) - FSH - Galanin (1, 2, 3) - Gonadotropin-releasing hormone (1, 2) - GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 79, 82, 83, 84, 85, 87, 88, 92, 101, 103, 119, 120, 132, 135, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 172, 173, 174, 176, 177, 182) - Ghrelin - Histamine (H1, H2, H3, H4) - Kisspeptin - Luteinizing hormone/choriogonadotropin - Lysophospholipid (1, 2, 3, 4, 5, 6, 7, 8) - MAS (1, 1L, D, E, F, G, X1, X2, X3, X4) - Melanocortin (1, 2, 3, 4, 5) - MCHR (1, 2) - Melatonin (1A, 1B)- Motilin - neuromedin (B, U (1, 2)) - Neuropeptide (B/W (1, 2), FF (1, 2), S, Y (1, 2, 4, 5)) - Neurotensin (1, 2) - Opioid (Delta, Kappa, Mu, Nociceptin, but not Sigma) - Olfactory - Opsin (3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH) - Orexin (1, 2) - Oxytocin - Oxoglutarate - PAF - Prokineticin (1, 2) - Prolactin-releasing peptide - Protease-activated (1, 2, 3, 4) - Purinergics (Adenosine (A1, A2a, A2b, A3), P2Y, (1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14)) - Relaxin (1, 2, 3, 4) - Somatostatin (1, 2, 3, 4, 5) - Serotonin, all but 5-HT3 (5-HT1 (A, B, D, E, F), 5-HT2 (A, B, C), 5-HT (4, 5A, 6, 7)) - SREB - Succinate - TAAR (1, 2, 3, 5, 6, 8, 9) - Tachykinin (1, 2, 3) - Thyrotropin - Thyrotropin-releasing hormone - Urotensin-II - Vasopressin (1A, 1B, 2)
Class B: Secretin like
Class C: Metabotropic
glutamate / pheromone
Calcium-sensing receptor - GABA B (1, 2) - Glutamate receptor (Metabotropic glutamate (1, 2, 3, 4, 5, 6, 7, 8)) - GPRC6A - GPR (156, 158, 179) - RAIG (1, 2, 3, 4) - Taste receptors (TAS1R (1, 2, 3) TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 38, 39, 40, 41, 43, 44, 45, 46, 47, 48, 49, 50))
Frizzled / Smoothened
Frizzled (1, 2, 3, 4, 5, 6, 7, 8, 9, 10) - Smoothened